WW domain-containing oxidoreductase (WWOX) gene

16q23.3-q24.1 Pathology: - the gene spans the 2nd most common chromosomal fragile site (FRA16D) which is frequently altered in cancers - alteration of expression & expression of some isoforms is associated with cancers - however, it is unclear if alteration of WWOX is directly implicated in cancerogenesis or if it corresponds to a secondary effect

Properties

TEMPLATE-FOR: messenger RNA TEMPLATE-FOR: WW domain-containing oxidoreductase LOCUS: human chromosome-16 MOTIF: transcription factor binding site transcriptional start site exon intron transcriptional termination site

Database Correlations

OMIM correlations MORBIDMAP 605131 Entrez Gene 51741

References

OMIM :accession 605131, 133239