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SARS CoV-2 RNA in specimen

Indication: - evaluation of viral infection with Wuhan coronavirus Clinical significance: - cycle thresholds > 24 & & time from symptom onset > 8 days associated with very low rates of positive viral cultures [4] Specimen: - respiratory specimens including: nasopharyngeal or oropharyngeal aspirates or washes, nasopharyngeal or oropharyngeal swabs, broncheoalveolar lavage, tracheal aspirates, & sputum - swab specimens with synthetic tip swabs (polyester or Dacron) with aluminum or plastic shafts - swabs with calcium alginate or cotton tips with wooden shafts may not be acceptable - patient-collected nasal & mid-turbinate samples may be appropriate for SARS-CoV-2 testing [5] - serum - storage: 2-4 C for [3] - nasal swab swirled in an open container with liquid chemicals potentially aerosolizing the virus

Specific

CovidNudge test Lucira SalivaDirect

General

coronavirus RNA

References

  1. Real-Time RT-PCR Panel for Detection 2019-Novel Coronavirus https://www.cdc.gov/coronavirus/2019-ncov/downloads/rt-pcr-panel-for-detection-instructions.pdf
  2. CPT :accession 87635
  3. Pradhan R Abbott's Fast COVID Test Poses Safety Issues, Lab Workers Say. Kaiser Health News. April 23, 2020 https://khn.org/news/abbotts-fast-covid-test-poses-safety-issues-lab-workers-say/
  4. Bullard J, Dust K, Funk] D et al. Predicting infectious SARS-CoV-2 from diagnostic samples. Clin Infect Dis 2020 May 22; [e-pub] PMID: 32442256 https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaa638/5842165
  5. Tu YP, Jennings R, Cangelosi GA, Wehber K Swabs Collected by Patients or Health Care Workers for SARS-CoV-2 Testing. N Engl J Med. June 3, 2020 PMID: 32492294 https://www.nejm.org/doi/full/10.1056/NEJMc2016321

Component-of

SARS CoV2/influenza virus in specimen