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WSXWS motif
Associated with 2 disulfide bridges in ligand-binding domain of hematopoietin receptor superfamily proteins. May facilitate hinge region. Tryptophans apparently involved in hydrophobic binding with ligand.
Related
hematopoietin receptor superfamily
General
peptide motif
exoplasmic motif
References
- Idzerda RL et al,
Human interleukin 4 receptor confers biological responsiveness
and defines a novel receptor superfamily.
J Exp Med 1990 Mar 1;171(3):861-73
PMID: 2403843