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wobble position
- generally 1st position in tRNA anticodon
- position of tRNA anticodon that allows non-Watson-Crick base pairing between nucleotide in tRNA-mRNA binding
- 4 main wobble base pairs are
a) guanine-uracil
b) inosine-uracil
c) inosine-adenine
d) inosine-cytosine
- thermodynamic stability of a wobble base pair is comparable to that of a Watson-Crick base pair
- wobble base pairs are essential for translation of mRNA
- most organisms have < 45 tRNAs, yet there are 64 possible codons (trinucleotide sequences) in mRNA; 3 are stop codons
General
biochemistry
References
- Wikipedia: Wobble base pair
http://en.wikipedia.org/wiki/Wobble_base_pair