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wnt1 proto-oncogene protein; int1 proto-oncogene protein; wingless (WNT1, INT1)
Function:
- ligand for members of the frizzled family
- probable developmental protein
- may be a signaling molecule important in CNS development
- likely to signal over only few cell diameters
- interacts with PORCN
- interacts with RSPO1, RSPO2 & RSPO3 (putative)
- Wnt1 signaling pathway inhibited by: DKK1, SOST, WIF1
Structure: belongs to the Wnt family
Compartment:
- secreted, extracellular space, extracellular matrix
Interactions
molecular events
Related
Wnt-1 signalling
wnt1 proto-oncogene or int1 proto-oncogene
General
secreted protein
wnt proto-oncogene protein or int proto-oncogene protein
Properties
SIZE: entity length = 370 aa
MW = 41 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-27}
N-glycosylation site {N29}
N-glycosylation site {N316}
N-glycosylation site {N346}
N-glycosylation site {N359}
References
- UniProt :accession P04628
- prosite :accession PS00246
- Entrez Gene :accession 7471
Databases & Figures
OMIM 164820
UniProt P04628
Pfam PF00110
Entrez Gene 7471
Kegg hsa:7471
Wnt1 signalling pathway