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Wilms tumor protein 1-interacting protein (WT1-interacting protein, WTIP)
Function:
- may monitor slit diaphragm protein assembly, a specialized adherens junction characteristic of podocytes
- in case of podocyte injury, shuttles into the nucleus & acts as a transcription regulator that represses WT1-dependent transcription regulation, thereby translating changes in slit diaphragm structure into altered gene expression & a less differentiated phenotype (putative)
- interacts with CD2AP & WT1 (putative)
Structure:
- belongs to the zyxin/ajuba family
- contains 3 LIM Zn+2-binding domains
Compartment:
- cell junction, adherens junction
- nucleus (putative)
- translocates from cell-cell junctions to the nucleus in puromycin aminonucleoside-treated podocytes (putative)
General
transcription factor (TF)
Properties
SIZE: entity length = 654 aa
MW = 67 kD
COMPARTMENT: cell nucleus
MOTIF: proline-rich region
SITE: 116-184
MOTIF: proline residue (SEVERAL)
glycine-rich region {189-378}
proline-rich region
SITE: 385-413
MOTIF: proline residue (SEVERAL)
LIM domain {447-508}
MOTIF: cysteine residue (6)
histidine residue
Zn+2-binding site
LIM domain {512-572}
MOTIF: cysteine residue (6)
histidine residue
Zn+2-binding site
LIM domain {573-641}
MOTIF: cysteine residue (6)
histidine residue
Zn+2-binding site
Database Correlations
UniProt A6NIX2
Pfam PF00412
References
UniProt :accession A6NIX2