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Wilms tumor gene, WAGR gene or wt1
Gene spans approximately 50 kilobases & contains 10 exons. 24 variants by alternative splicing, RNA editing & alternative. start sites. 3 distinct transcripts identified associated with 1 CpG island. WAGR gene (Wilm's tumor/aniridia/genito-urinary anomaly/mental retardation.
Related
Wilms' tumor protein; WT1 protein (WT1, WT3)
General
tumor suppressor gene or anti-oncogene
Properties
TEMPLATE-FOR: messenger RNA
TEMPLATE-FOR: Wilms' tumor protein
LOCUS: human chromosome-11 P13
MOTIF: transcription factor binding site
transcriptional start site
exon
intron
transcriptional termination site
Database Correlations
OMIM correlations
References
- Huang et al Science 250:991 1990
- Bonetta et al Science 250:994 1990