Search
Wee1-like protein kinase 1B; Wee1B kinase (WEE1B, WEE2)
Function:
1) phosphorylates & inhibits CDC2
2) negative regulator of entry into mitosis (G2 to M transition)
4) phosphorylated
Structure:
- contains 1 protein kinase domain
Compartment: nucleus
Expression: expressed in testis
General
tyrosine kinase (protein tyrosine kinase, PTK)
Properties
SIZE: MW = 63 kD
entity length = 567 aa
COMPARTMENT: cell nucleus
STATE: active state
MOTIF: kinase domain
SITE: 212-486
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 218-226
ATP-binding site
NAME: ATP-binding site
SITE: 241-241
aspartate residue {D339}
coiled coil {494-519}
Database Correlations
UniProt P0C1S8
Pfam PF00069
ENZYME 2.7.10.2
References
UniProt :accession P0C1S8