DDB1- & CUL4-associated factor 7; WD repeat-containing protein 68; WD repeat-containing protein An11 homolog (DCAF7, HAN11, WDR68)

Function: - role in craniofacial development - acts upstream of the EDN1 pathway - required for formation of the upper jaw equivalent, the palatoquadrate - activity required for EDN1 pathway function differs between 1st & 2nd arches - associates with DIAPH1; controls GLI1 transcriptional activity - could be involved in skin development - may function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex - protein modification; protein ubiquitination - interacts with DYRK1A, DYRK1B & DIAPH1 - interacts with DDB1 Structure: - belongs to the WD repeat DCAF7 family - contains 4 WD repeats Compartment: - cytoplasm. nucleus - overexpression of DIAHP1 or active RHOA causes translocation from the nucleus to cytoplasm

General

nuclear protein WD repeat protein family

Properties

SIZE: entity length = 342 aa MW = 39 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: WD repeat {66-108} WD repeat {118-160} WD repeat {172-214} WD repeat {264-304}

Database Correlations

OMIM 605973 UniProt P61962 Pfam PF00400 Entrez Gene 10238 Kegg hsa:10238

References

UniProt :accession O15491