WD repeat protein 79; telomerase Cajal body protein 1; WD40 repeat-containing protein encoding RNA antisense to p53 (WRAP53 TCAB1 WDR79)

Function: - phosphorylated upon DNA damage, probably by ATM or ATR - component of the telomerase holoenzyme complex - controls telomerase localization to Cajal body - required for delivery of TERC to telomeres during S phase & for telomerase activity - binds small Cajal body RNAs (scaRNAs) - the mRNA encoding this protein plays a role in regulation of p53 expression at the post-transcriptional level - it is involved both in maintaining basal p53 mRNA levels & in p53 induction upon DNA damage - phosphorylated upon DNA damage, probably by ATM or ATR Structure: contains 6 WD repeats Compartment: nucleus, Cajal body. cytoplasm Expression: - expressed in all tissues & cell lines examined Pathology: - defects in WRAP53 are the cause of autosomal recessive dyskeratosis congenita type 3

General

nuclear protein phosphoprotein WD repeat protein family

Properties

SIZE: entity length = 548 aa MW = 59 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: proline-rich region SITE: 8-57 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S26} Ser phosphorylation site {S30} Ser phosphorylation site {S54} Ser phosphorylation site {S64} Ser phosphorylation site {S85} Ser phosphorylation site {S90} Ser phosphorylation site {S112} Ser phosphorylation site {S114} WD repeat {167-206} WD repeat {222-267} WD repeat {272-313} WD repeat {323-364} WD repeat {365-405} WD repeat {411-450} Thr phosphorylation site {T489} Ser phosphorylation site {S491}

Database Correlations

OMIM correlations UniProt Q9BUR4 Pfam PF00400 Entrez Gene 55135 Kegg hsa:55135

References

UniProt :accession Q9BUR4