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WD repeat-containing protein 4; tRNA (guanine-N(7)-)-methyltransferase subunit WDR4 (WDR4)
Function:
- required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
- forms a complex with METTL1 (tRNA guanine-N7-methyltransferase)
- in the complex, it is required to stabilize & induce conformational change of the catalytic subunit
- tRNA modification; N(7)-methylguanine-tRNA biosynthesis
Structure:
- belongs to the WD repeat TRM82 family
- contains 4 WD repeats
Compartment: nucleus
Alternative splicing: named isoforms=3
General
nuclear protein
phosphoprotein
protein subunit
WD repeat protein family
Properties
SIZE: entity length = 412 aa
MW = 45 kD
COMPARTMENT: cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
WD repeat {59-98}
WD repeat {143-183}
WD repeat {186-226}
WD repeat {287-327}
Ser phosphorylation site {S391}
Ser phosphorylation site {S411}
Database Correlations
OMIM 605924
UniProt P57081
Pfam PF00400
Entrez Gene 10785
Kegg hsa:10785
References
- UniProt :accession P57081
- OMIM :accession 605924