WD repeat protein family

Contains highly conserved repeating units usually ending with Trp-Asp. Found in eukaryotes, but not prokaryotes. Involved in signal transduction, RNA processing, gene regulation, development, vesicular traffic, regulation of cytoskeletal assembly & the cell cycle.

Specific

actin-related protein 2/3 complex subunit 1A; SOP2-like protein (ARPC1A, SOP2L) actin-related protein 2/3 complex subunit 1B; Arp2/3 complex 41 kD subunit; p41-ARC (ARPC1B, ARC41) activating molecule in BECN1-regulated autophagy protein 1 (AMBRA1, KIAA1736) aladin (adracalin, AAAS, ADRACALA, GL003) apoptotic protease-activating factor 1; APAF-1 (APAF1, KIAA0413) autophagy protein 16-like; autophagy-related protein 16-1; APG16-like 1 (ATG16L1, APG16L, UNQ9393/PRO34307) autophagy-related protein 16-2 (APG16-like 2, WD repeat-containing protein 80, ATG16L2, WDR80) breast carcinoma amplified sequence 3 (GAOB1, Maab1 protein, BCAS3) bromodomain & WD repeat domain-containing protein 3 (BRWD3) BTB/POZ domain-containing protein KCTD3 (renal carcinoma antigen NY-REN-45, KCTD3) cell division cycle protein 20 homolog B (CDC20B) cell division cycle protein 20 homolog; p55CDC (CDC20) cleavage stimulation factor 50 kD subunit; CSTF 50 kD subunit; CF-1 50 kD subunit; CstF-50 (CSTF1) CMT1A duplicated region transcript 1 protein (CDRT1, C17orf1, C17orf1A, HREP) coatomer subunit alpha; alpha-coat protein; alpha-COP; HEP-COP; HEPCOP; contains: xenin; xenopsin-related peptide; contains: proxenin (COPA) coatomer subunit beta'; beta'-coat protein; beta'-COP; p102 (COPB2) constitutive photomorphogenic protein 1 (E3 ubiquitin-protein ligase RFWD2, RING finger & WD repeat domain protein 2, RFWD2) coronin coronin-7; Crn7; 70 kD WD repeat tumor rejection antigen homolog (CORO7) DDB1- & CUL4-associated factor 4; WD repeat-containing protein 21A (DCAF4, WDR21, WDR21A) denticleless protein homolog (Lethal(2) denticleless protein homolog, Ddb1- & Cul4-associated factor 2, retinoic-acid regulated nuclear matrix-associated protein, DTL, CDT2, CDW1, DCAF2, L2DTL, RAMP) DmX-like protein 2; rabconnectin-3 (DMXL2, KIAA0856) DNA damage-binding protein 2; damage-specific DNA-binding protein 2; DDB p48 subunit; DDBb; UV-damaged DNA-binding protein 2; UV-DDB 2 (DDB2) DNA excision repair protein ERCC-8; Cockayne syndrome WD repeat protein CSA (ERCC8, CKN1, CSA) dynein intermediate chain 1, axonemal (DNAI1) dynein intermediate chain 1, cytosolic (DH IC-1, DYNC1I1, DNCI1, DNCIC1,) dynein intermediate chain 2, axonemal dynein intermediate chain 2, cytosolic (DYNC1I2) dystrophia myotonica WD repeat-containing protein (dystrophia myotonica-containing WD repeat motif protein, DMR-N9 protein, protein 59, DMWD, DM9) E3 ubiquitin-protein ligase HERC1 (HECT domain & RCC1-like domain-containing protein 1, p532, p619, HERC1) E3 ubiquitin-protein ligase LNX; ligand of Numb-protein X 1; Numb-binding protein 1 (LNX1, LNX, UNQ574/PRO1136) E3 ubiquitin-protein ligase TRAF7; RING finger & WD repeat-containing protein 1; RING finger protein 119; TNF receptor-associated factor 7 (TRAF7, RFWD1, RNF119) Echinoderm microtubule-associated protein-like 1; EMAP-1; HuEMAP-1 (EML1, EMAP1, EMAPL, EMAPL1) echinoderm microtubule-associated protein-like 2 (EMAP-2, HuEMAP-2, EML2, EMAP2, EMAPL2) Echinoderm microtubule-associated protein-like 3 (EMAP-3, EML3) echinoderm microtubule-associated protein-like 4; EMAP-4; restrictedly overexpressed proliferation-associated protein; Ropp 120 (EML4, C2orf2, EMAPL4) Echinoderm microtubule-associated protein-like 5 (EMAP-5, EML5) EML5L-like protein (EML5LL, EML6) enhancer of mRNA-decapping protein 4 (human enhancer of decapping large subunit, Hedls, autoantigen Ge-1, autoantigen RCD-8, EDC4, HEDLS) eukaryotic initiation factor 3 subunit 2 (eIF-3 beta, eiF3 p36, TGF-beta receptor-interacting protein-1, trip1, EIF3I) eukaryotic translation initiation factor 2A (eIF-2A, 65 kD eukaryotic translation initiation factor 2A, EIF2A) F-box & WD-repeat protein factor associated with neutral sphingomyelinase activation; protein FAN; factor associated with N-smase activation (NSMAF, FAN) Fizzy-related protein homolog; Fzr; Cdh1/Hct1 homolog; hCDH1; CDC20-like protein 1 (FZR1, CDH1, FYR, FZR, KIAA1242) glutamate-rich WD repeat-containing protein 1 (GRWD1, GRWD, KIAA1942, WDR28) GTP-binding regulatory protein beta guanine nucleotide-binding protein subunit beta-2-like 1; guanine nucleotide-binding protein subunit beta-like protein 12.3; receptor of activated protein kinase C 1; RACK1; receptor for activated C kinase; cell proliferation-inducing gene 21 protein; Human lung cancer oncogene 7 protein; HLC-7 (GNB2L1) histone-binding protein RBBP4; retinoblastoma-binding protein 4; RBBP-4; retinoblastoma-binding protein p48; chromatin assembly factor 1 subunit C; CAF-1 subunit C; chromatin assembly factor I p48 subunit; CAF-I 48 kD subunit; CAF-I p48; nucleosome-remodeling factor subunit RBAP48 (RBBP4, RbAp48) histone-binding protein RBBP7; retinoblastoma-binding protein 7; RBBP-7; retinoblastoma-binding protein p46; histone acetyltransferase type B subunit 2; nucleosome-remodeling factor subunit RBAP46 (RBBP7, RBAP46, HAT2) intraflagellar transport 140 homolog (WD & tetratricopeptide repeats protein 2, IFT140, KIAA0590, WDTC2) intraflagellar transport protein 172 homolog (IFT172, KIAA1179) jouberin; Abelson helper integration site 1 protein homolog (AHI-1, AHI1) Lethal(2) giant larvae protein homolog 1 (LLGL, human homolog to the D-lgl gene, Hugl-1, DLG4, LLGL1, HUGL) lethal(2) giant larvae protein homolog 2 (HGL, LLGL2) leucine-rich repeat & WD repeat-containing protein 1 (LRWD1) Leucine-rich repeat & WD repeat-containing protein KIAA1239 (KIAA1239) lipopolysaccharide-responsive & beige-like anchor protein; Beige-like protein; CDC4-like protein (LRBA, BGL, CDC4L, LBA) lysosomal-trafficking regulator; Beige homolog (LYST, CHS, CHS1) mitogen-activated protein kinase-binding protein 1 (JNK-binding protein 1, JNKBP1, MAPKBP1, JNKBP1, KIAA0596) mitotic checkpoint protein BUB3 (budding inhibitied by benzimidazoles, BUB3) NACHT & WD repeat domain-containing protein 1 (NWD1) NEDD1 protein; neural cell expressed developmentally down-regulated protein 1; NEDD-1 (NEDD1) neurobeachin-like protein 2 (NBEAL2 KIAA0540 UNQ253/PRO290) neuroblastoma-amplified gene protein (NAG, NBAS) notchless protein homolog 1; WD repeat protein HUSSY-07 (NLE1) nuclear receptor interaction protein; NRIP; IQ motif & WD repeat-containing protein 1; androgen receptor complex-associated protein (ARCAP, IQWD1, DCAF6) nucleolar protein 10 (NOL10) p21-activated protein kinase-interacting protein 1; PAK1-interacting protein 1; PAK/PLC-interacting protein 1; hPIP1 (PAK1IP1, PIP1, WDR84) partner & localizer of BRCA2 ( PALB2, FANCN) periodic tryptophan protein 2 homolog (PWP2H, PWP2) peroxisomal targeting signal 2 receptor; PTS2 receptor; peroxin-7 (PEX7 PTS2R) PH-interacting protein (PHIP, IRS-1 PH domain-binding protein, WD repeat-containing protein 11, PHIP, WDR11) phosphatase-2A 55 kD regulatory subunit B gamma (PP2A, subunit B, B-gamma isoform; PP2A, subunit B, B55-gamma isoform; PP2A, subunit B, PR55-gamma isoform; PP2A, subunit B, R2-gamma isoform; IMYPNO1; PPP2R2C) phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4, PI3-kinase p150 subunit, phosphoinositide 3-kinase adaptor protein, PIK3R4) phospholipase A-2-activating protein; PLA2P; PLAP (PLAA PLAP) platelet-activating factor acetylhydrolase IB subunit alpha; PAF acetylhydrolase 45 kD subunit; PAF-AH 45 kD subunit; PAF-AH alpha; PAFAH alpha; Lissencephaly-1 protein; LIS-1 (PAFAH1B1, LIS1, MDCR, MDS, PAFAHA) pleiotropic regulator 1 (PLRG1) polycomb protein EED; hEED; WD protein associating with integrin cytoplasmic tails 1; WAIT-1 (EED) pre-mRNA-processing factor 19 (PRP19/PSO4 homolog, hPso4, nuclear matrix protein 200, senescence evasion factor, PRPF19, NMP200, PRP19, SNEV) prolactin regulatory element-binding protein; mammalian guanine nucleotide exchange factor msec12 (PREB, SEC12) protein DmX-like 1; X-like 1 protein (DMXL1, XL1) protein neurobeachin; lysosomal-trafficking regulator 2; protein; BCL8 (NBEA, BCL8B, KIAA1544, LYST2) protein RIC1 homolog (connexin 43-interacting protein of 150 kD) (KIAA1432 CIP150) protein transport protein Sec31A (SEC31-related protein A, SEC31-like 1, ABP125, ABP130, Web1-like protein, SEC31A, KIAA0905, SEC31L1, HSPC275, HSPC334) protein transport protein Sec31B; SEC31-related protein B; SEC31B-1; SEC31-like 2 (SEC31B, SEC31L2) regulatory-associated protein of mTOR; Raptor; P150 target of rapamycin (TOR)-scaffold protein (RPTOR, KIAA1303) retinoblastoma-binding protein 5; RBBP-5; retinoblastoma-binding protein RBQ-3 (RBBP5, RBQ3) ribosome biogenesis protein BOP1 (block of proliferation 1 protein, BOP1, KIAA0124) RING finger & WD repeat domain-containing protein 3 (RING finger protein 201, RFWD3, RNF201) serine-threonine kinase receptor-associated protein; MAP activator with WD repeats; UNR-interacting protein; WD-40 repeat protein PT-WD (STRAP, MAWD, UNRIP) serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B delta (PP2A, subunit B, B-delta isoform; PP2A, subunit B, B55-delta isoform; PP2A, subunit B, PR55-delta isoform; PP2A, subunit B, R2-delta isoform, PPP2R2D, KIAA1541) SH3KBP1-binding protein 1 (SHKBP1) sperm-associated antigen 16 protein (Pf20 protein homolog, SPAG16, PF20) stat3-interacting protein (StIP1, ELP2, SHINC-2, STATIP1) sterol regulatory element-binding protein cleavage-activating protein; SREBP cleavage-activating protein; SCAP (SCAP, KIAA0199, PSEC0227) striatin (STRN) striatin-3; cell cycle autoantigen SG2NA; S/G2 antigen (STRN3, GS2NA, SG2NA) striatin-4; zinedin (STRN4 ZIN) syntaxin-binding protein 5-like (tomosyn-2, lethal[2] giant larvae protein homolog 4, STXBP5L, KIAA1006, LLGL4) TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kD subunit 5L; PCAF-associated factor 65-beta; PAF65-beta (TAF5L, PAF65B) target of rapamycin complex subunit LST8; TORC subunit LST8; G protein beta subunit-like; Gable; protein GbetaL; mammalian lethal with SEC13 protein 8; mLST8 (MLST8, GBL, LST8) Tectonin beta-propeller repeat-containing protein 2; WD repeat-containing protein KIAA0329/KIAA0297 (TECPR2, KIAA0297, KIAA0329) telomerase protein component 1 (TEP1, p240, p80 telomerase homolog) THO complex subunit 3 (Tho3, TEX1 homolog, THOC3) transcription initiation factor TFIID subunit 5; p100TFIID; transcription initiation factor TFIID 100 kD subunit; TAF(II)100; TAFII-100; TAFII100 (TAF5, TAF2D) transducin beta-like protein 3; WD repeat-containing protein SAZD (TBL3 SAZD) transducin-like enhancer protein (ESG) tubby-related protein 4; tubby superfamily protein; tubby-like protein 4 (TULP4, KIAA1397, TUBL4, TUSP) U3 small nucleolar RNA-associated protein 15 homolog (UTP15) U3 small nucleolar RNA-associated protein 18 homolog; WD repeat-containing protein 50 (UTP18, WDR50, CDABP0061, CGI48) U4/U6 small nuclear ribonucleoprotein Prp4; U4/U6 snRNP 60 kD protein; WD splicing factor Prp4; hPrp4 (PRPF4) WD & tetratricopeptide repeats protein 1 (WDTC1, KIAA1037) WD repeat & FYVE domain containing protein 3 (autophagy-linked FYVE protein, Alfy, WDFY3, KIAA0993) WD repeat & FYVE domain-containing protein 1; FENS-1; phosphoinositide-binding protein 1; WD40- & FYVE domain-containing protein 1; zinc finger FYVE domain-containing protein 17 (WDFY1, KIAA1435, WDF1, ZFYVE17) WD repeat & FYVE domain-containing protein 2; WD40- & FYVE domain-containing protein 2; zinc finger FYVE domain-containing protein 22 (WDFY2, WDF2, ZFYVE22) WD repeat & HMG-box DNA-binding protein 1 (acidic nucleoplasmic DNA-binding protein 1, And-1, WDHD1, AND1) WD repeat & SOCS box-containing protein 1; WSB-1; SOCS box-containing WD protein SWiP-1 (WSB1, SWIP1) WD repeat & SOCS box-containing protein 2; WSB-2; CS box-containing WD protein (WSB2) WD repeat & SOF domain-containing protein 1; DDB1- & CUL4-associated factor 13 (DCAF13, WDSOF1, HSPC064) WD repeat domain phosphoinositide-interacting protein 1 (WIPI-1, WD40 repeat protein interacting with phosphoinositides of 49 kD, WIPI 49 kD, Atg18 protein homolog, WIPI1, WIPI49) WD repeat domain phosphoinositide-interacting protein 2 (WIPI-2, WIPI49-like protein 2, WIPI2) WD repeat domain phosphoinositide-interacting protein 3; WIPI-3; WD repeat-containing protein 45-like; WDR45-like protein; WD repeat-containing protein 45B; WIPI49-like protein (WDR45B, WDR45L, WIPI3) WD repeat domain phosphoinositide-interacting protein 4 (WIPI-4, WD repeat protein 45, WDR45, WDRXI4, WIPI4, JM5) WD repeat protein 16 (WD40-repeat protein up-regulated in HCC, WDR16, WDRPUH) WD repeat protein 19 (WDR19, KIAA1638) WD repeat protein 21B; DDB1- & CUL4-associated factor 4-like protein 1 (WDR21B, LOC285429, DCAF4L1) WD repeat protein 21C (WDR21C, DCAF4L2) WD repeat protein 24 (WDR24) WD repeat protein 25 (WDR25) WD repeat protein 41 (WDR41) WD repeat protein 43 WD repeat protein 44 (rabphilin-11 WDR44) WD repeat protein 47 (WDR47, KIAA0893) WD repeat protein 48 (WD repeat endosomal protein, p80, WDR48, KIAA1449) WD repeat protein 49 (WDR49) WD repeat protein 51A (WDR51A, POC1A) WD repeat protein 51B (WDR51B, POC1B) WD repeat protein 53 (WDR53) WD repeat protein 54 (WDR54) WD repeat protein 55 (WDR55) intraflagellar transport 80 homolog (WD repeat protein 56, IFT80, KIAA1374, WDR56) WD repeat protein 57; Prp8-binding protein; hPRP8BP; U5 snRNP-specific 40 kD protein; 38 kD-splicing factor (WDR57, SNRNP40, PRP8BP, SFP38) WD repeat protein 58 (THO complex subunit 6 homolog, THOC6, WDR58, PSEC0006) WD repeat protein 59 (WDR59, KIAA1923, FP977) WD repeat protein 5B (WDR5B) WD repeat protein 60 (WDR60) WD repeat protein 61 (meiotic recombination REC14 protein homolog, WDR61) WD repeat protein 62 (WDR62, C19orf14) WD repeat protein 63 (Testis development protein NYD-SP29, WDR63) WD repeat protein 65 (WDR65) WD repeat protein 71 (proteasomal ATPase-associated factor 1, protein G-16, WDR71, PAAF1) WD repeat protein 72 (WDR72) WD repeat protein 74 (NOP seven-associated protein 1, WDR74, NSA1) WD repeat protein 75 (WDR75) WD repeat protein 76 (WDR76) methylosome protein 50 (MEP50 protein, WD repeat protein 77, WDR77, MEP50) WD repeat protein 78 (WDR78) WD repeat protein 79; telomerase Cajal body protein 1; WD40 repeat-containing protein encoding RNA antisense to p53 (WRAP53 TCAB1 WDR79) WD repeat protein 81 (WDR81) WD repeat protein 82 (WDR82) WD repeat protein 88 (PQQ repeat & WD repeat-containing protein, WDR88, PQWD) WD repeat protein 89 (WDR89, C14orf150, MST050) WD repeat, SAM & U-box domain-containing protein 1 (WDSUB1, WDSAM1) WD repeat-containing protein 10; intraflagellar transport protein 122 homolog (IFT122, SPG, WDR10, WDR140) WD repeat-containing protein 11; bromodomain & WD repeat-containing protein 2; WD repeat-containing protein 15 (WDR11, BRWD2, KIAA1351, WDR15) WD repeat-containing protein 12; ribosome biogenesis protein WDR12 (WDR12) WD repeat-containing protein 13 (WDR13) guanine nucleotide-binding protein subunit beta-like protein 1; G protein subunit beta-like protein 1; DGCRK3; WD repeat-containing protein 14; WD40 repeat-containing protein deleted in VCFS; WDVCF (GNB1L, GY2, KIAA1645, WDR14, FKSG1) WD repeat-containing protein 17 (WDR17) WD repeat-containing protein 18 (WDR18) WD repeat-containing protein 1; actin-interacting protein 1; AIP1; NORI-1 (WDR1) WD repeat-containing protein 20; protein DMR (WDR20) WD repeat-containing protein 22; DDB1- & CUL4-associated factor 5; breakpoint cluster region protein 2; BCRP2 (DCAF5, BCRG2, KIAA1824, WDR22) WD repeat-containing protein 23; DDB1- & CUL4-associated factor 11 (DCAF11, WDR23, GL014, PRO2389) WD repeat-containing protein 26; CUL4- & DDB1-associated WDR protein 2; myocardial ischemic preconditioning up-regulated protein 2 (WDR26, CDW2, MIP2, PRO0852) WD repeat-containing protein 27 (WDR27) WD repeat-containing protein 3 (WDR3) WD repeat-containing protein 31 (WDR31) WD repeat-containing protein 32 (WDR32, DCAF10) WD repeat-containing protein 33; WD repeat-containing protein WDC146 (WDR33, WDC146) WD repeat-containing protein 34 (WDR34) WD repeat-containing protein 35 (WDR35 KIAA1336) WD repeat-containing protein 36; T-cell activation WD repeat-containing protein; TA-WDRP (WDR36) WD repeat-containing protein 37 (WDR37 KIAA0982) WD repeat-containing protein 39; cytosolic iron-sulfur protein assembly protein CIAO1 (CIAO1, WDR39) WD repeat-containing protein 40A; centrosome-related protein TCC52 (WDR40A, DCAF12, KIAA1892) WD repeat-containing protein 40B (WDR40B, DCAF12L1) WD repeat-containing protein 40C (WDR40C, DCAF12L2) WD repeat-containing protein 42A (WDR42A, DCAF8, H326) WD repeat-containing protein 42B (WDR42B, DCAF8L1) WD repeat-containing protein 42C (WDR42C, DCAF8L2) WD repeat-containing protein 46; WD repeat-containing protein BING4 (WDR46, BING4, C6orf11, FP221) WD repeat-containing protein 4; tRNA (guanine-N(7)-)-methyltransferase subunit WDR4 (WDR4) WD repeat-containing protein 52 (WDR52) WD repeat-containing protein 5; BMP2-induced 3-kb gene protein (WDR5, BIG3) WD repeat-containing protein 6 (WDR6) WD repeat-containing protein 64 (WDR64) WD repeat-containing protein 66 (WDR66) WD repeat-containing protein 67; TBC1 domain family member 31 (TBC1D31, WDR67) DDB1- & CUL4-associated factor 7; WD repeat-containing protein 68; WD repeat-containing protein An11 homolog (DCAF7, HAN11, WDR68) WD repeat-containing protein 69; dynein assembly factor with WDR repeat domains 1; outer row dynein assembly protein 16 homolog (DAW1, WDR69) WD repeat-containing protein 70 (WDR70) WD repeat-containing protein 73 (WDR73) WD repeat-containing protein 7; TGF-beta resistance-associated protein TRAG; Rabconnectin-3 beta (WDR7, KIAA0541, TRAG) WD repeat-containing protein 8 (WDR8, WRAP73) WD repeat-containing protein 85; diphthamide biosynthesis protein 7 (DPH7, C9orf112, WDR85) WD repeat-containing protein 86 (WDR86) WD repeat-containing protein 87 (testis development protein NYD-SP11, WDR87) WD repeat-containing protein 90 (WDR90, C16orf15, C16orf16, C16orf17, KIAA1924) WD repeat-containing protein 91 (WDR91) WD repeat-containing protein 92 (WD repeat-containing protein monad, WDR92) WD repeat-containing protein 93 (WDR93) WD repeat-containing protein 9; bromodomain & WD repeat-containing protein 1 (BRWD1, C21orf107, WDR9) WD repeat-containing protein C10orf79 (WDR96) WD repeat-containing protein C2orf44 (C2orf44) WD repeat-containing protein KIAA1875 (KIAA1875) WD repeat-containing protein LOC51057 (WDPCP) WD repeat-containing protein mio (MIOS) zinc finger protein 106 homolog; zinc finger protein 474 (ZNF474, Zfp-106, ZFP106)

Properties

MOTIF: WD repeat

References

Neer et al. Nature 371:297-300 1994