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WAS protein family homolog 6; protein FAM39A (WASH6P, CXYorf1, FAM39A)
Function:
- acts as a nucleation-promoting factor at the surface of endosomes
- recruits & activates the Arp2/3 complex to induce actin polymerization
- role in fission of tubules that serve as transport intermediates during endosome sorting
- component of the WASH complex
- interacts (via WHD1 region) with FAM21C
Structure:
- belongs to the WASH1 family
- contains 1 WH2 domain
Compartment:
- early endosome membrane
- recycling endosome membrane
- localization to the endodome membrane is mediated via its interaction with FAM21
Alternative splicing: named isoforms=2
Genetics:
- WASH genes duplicated to multiple chromosomal ends during primate evolution, with highest copy number reached in humans, whose WASH repertoires probably vary extensively among individuals [2]
- the gene encoding for this protein is located in the pseudoautosomal region 2 (PAR2) of X & Y chromosomes
General
WAS protein family homolog; protein FAM39DP (WASH)
Properties
SIZE: entity length = 447 aa
MW = 48 kD
COMPARTMENT: cytoplasm
MOTIF: WHD1 {1-149}
proline-rich region
SITE: 250-312
MOTIF: proline residue (SEVERAL)
WH2 {343-365}
Database Correlations
UniProt Q9NQA3
Pfam PF11945
References
- UniProt :accession Q9NQA3
- Linardopoulou EV et al
Human subtelomeric WASH genes encode a new subclass of the
WASP family.
PLoS Genet. 2007 Dec;3(12):e237.
PMID: 18159949