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WAS protein family homolog 3; protein FAM39DP (WASH3P, FAM39DP)
Function:
- acts as a nucleation-promoting factor at the surface of endosomes, where it recruits & activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (putative)
- component of the WASH complex
- interacts (via WHD1 region) with FAM21C
Structure:
- belongs to the WASH1 family
- contains 1 WH2 domain
Compartment:
- early endosome membrane (putative)
- recycling endosome membrane (putative)
- localization to the endodome membrane is mediated via its interaction with FAM21
Genetics:
- WASH genes duplicated to multiple chromosomal ends during primate evolution, with highest copy number reached in humans, whose WASH repertoires probably vary extensively among individuals [2]
- it is therefore difficult to determine which gene is functional or not
- the telomeric region of chromosome 9p is paralogous to the pericentromeric regions of chromosome 9 as well as to 2q
- paralogous regions contain 7 transcriptional units
- duplicated WASH genes are also present in the Xq/Yq pseudoautosomal region, as well as on chromosome 1 & chromosome 15
- the chromosome 16 copy seems to be a pseudogene
General
WAS protein family homolog; protein FAM39DP (WASH)
Properties
SIZE: entity length = 463 aa
MW = 50 kD
COMPARTMENT: cytoplasm
MOTIF: WHD1 {1-165}
proline-rich region
SITE: 266-328
MOTIF: proline residue (SEVERAL)
serine-rich region {338-345}
MOTIF: serine residue (SEVERAL)
WH2 {359-381}
Database Correlations
UniProt C4AMC7
References
- UniProt :accession C4AMC7
- Linardopoulou EV et al
Human subtelomeric WASH genes encode a new subclass of the
WASP family.
PLoS Genet. 2007 Dec;3(12):e237.
PMID: 18159949