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WAS protein family homolog; protein FAM39DP (WASH)

Function: - presumbly cytoskeletal proteins - components of WASH complex Genetics: - WASH genes duplicated to multiple chromosomal ends during primate evolution, with highest copy number reached in humans, whose WASH repertoires probably vary extensively among individuals [2] - it is therefore difficult to determine which gene is functional or not - the telomeric region of chromosome 9p is paralogous to the pericentromeric regions of chromosome 9 as well as to 2q - paralogous regions contain 7 transcriptional units - duplicated WASH genes are also present in the Xq/Yq pseudoautosomal region, as well as on chromosome 1 & chromosome 15 - the chromosome 16 copy seems to be a pseudogene

Specific

WAS protein family homolog 1; protein FAM39E; CXYorf1-like protein on chromosome 9 (WASH1, FAM39E) WAS protein family homolog 3; protein FAM39DP (WASH3P, FAM39DP) WAS protein family homolog 4; protein FAM39CP (WASH4P FAM39CP) WAS protein family homolog 6; protein FAM39A (WASH6P, CXYorf1, FAM39A)

General

cytoskeletal protein evolutionary divergent human protein

Properties

COMPARTMENT: cytoplasm

References

  1. UniProt :accession C4AMC7
  2. Linardopoulou EV et al Human subtelomeric WASH genes encode a new subclass of the WASP family. PLoS Genet. 2007 Dec;3(12):e237. PMID: 18159949

Component-of

WASH complex