Search
WAS/WASL-interacting protein family member 3 (corticosteroids & regional expression protein 16 homolog, WIPF3, CR16)
Function:
- may be a regulator of cytoskeletal organization
- may have a role in spermatogenesis (putative)
- interacts with WASL, & monomeric & filamentous actin
Structure:
- the WH2 domain is found in a number of putative actin- binding proteins (putative)
- the profilin-binding motif has been implicated in the interaction with profilin & SH3 domains (putative)
- the KLKR motif is essential for G-actin binding & for actin polymerization (putative)
- belongs to the verprolin family
- contains 1 WH2 domain
Compartment:
- cytoplasm
- in hippocampal neurons. colocalizes with WASL in the cell body, axons & the growth cone
General
cytoskeletal protein
Properties
SIZE: entity length = 483 aa
MW = 49 kD
COMPARTMENT: cytoplasm
MOTIF: Profilin-binding {3-8}
Profilin-binding {11-16}
Profilin-binding {20-25}
WH2 {45-62}
MOTIF: RLRK {58-61}
proline-rich region
SITE: 172-191
MOTIF: proline residue (SEVERAL)
proline-rich region
SITE: 223-239
MOTIF: proline residue (SEVERAL)
proline-rich region
SITE: 289-298
MOTIF: proline residue (SEVERAL)
WASP-binding {424-448}
Database Correlations
UniProt A6NGB9
Pfam PF02205
References
UniProt :accession A6NGB9