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warfarin sensitivity testing (CYP2C8, CYP2C9, CYP4F2, VKORC1)

Indications: - initiating warfarin therapy - history of unstable warfarin dosing - risk for bleeding events while receiving warfarin therapy Procedure: - Invader Warfarin Sensitivity Molecular Assay - detection of common allelic variants in cytochrome P450 2C9 & vitamin K epoxide reductase complex subunit-1 (VKORC1) genes, including CYP2C9*1, CYP2C9*2 (3608C>T), CYP2C9*3 (42614A>C) & VKORC1 -1639G>A - utilizes polymerase chain reaction (PCR) Specimen: - lavender top, do not freeze Laboratory: - see ARUP consult [3]

Specific

CYP2C9 allele vitamin K epoxide reductase allele/allele (VKORC1 gene mutation)

General

DNA (genetic) testing

References

  1. Warfarin Sensitivity Testing (CYP2C9 and VKORC1) Barnes Jewish Hospital Washington University in St Louis http://pathology.wustl.edu/patientcare/pdf/warfarin.pdf
  2. Mini Panel of 2 tests: CYP2C9 Allele 2 . CYP2C9 Gene Mutation Interpretation Laboratory Test Directory ARUP: 51103
  3. ARUP Consult: Warfarin Sensitivity (CYP2C8, CYP2C9, CYP4F2, VKORC1) Genotyping https://arupconsult.com/ati/warfarin-sensitivity-genotyping