WAP, kazal, immunoglobulin, kunitz & NTR domain-containing protein 1 (WAP, follistatin, immunoglobulin, kunitz & NTR domain-containing protein, growth & differentiation factor-associated serum protein 2, GASP-2, hGASP-2, WFIKKN1, GASP2, WFIKKN, PSEC0040)

Function: - protease-inhibitor - contains multiple distinct protease inhibitor domains - probably has serine protease- & metalloprotease-inhibitor activity Structure: - belongs to the WFIKKN family - contains 2 BPTI/Kunitz inhibitor domains 2nd BPTI/Kunitz inhibitor domain is able to inhibit trypsin; however, it has no activity toward chymotrypsin, elastase, plasmin, pancreatic kallikrein, lung tryptase, plasma kallikrein, thrombin, urokinase or tissue plasminogen activator - contains 1 Ig-like C2-type domain (immunoglobulin-like) - contains 1 Kazal-like domain - contains 1 NTR domain - contains 1 WAP domain Compartment: secreted (putative) Expression: - expressed in pancreas, kidney, liver, placenta, & lung

Properties

SIZE: entity length = 548 aa MW = 59 kD COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-19} WAP {29-78} MOTIF: cysteine residue {C33} MODIFICATION: cysteine residue {C66} cysteine residue {C49} MODIFICATION: cysteine residue {C70} cysteine residue {C53} MODIFICATION: cysteine residue {C65} cysteine residue {C59} MODIFICATION: cysteine residue {C75} cysteine residue {C65} MODIFICATION: cysteine residue {C53} cysteine residue {C66} MODIFICATION: cysteine residue {C33} cysteine residue {C70} MODIFICATION: cysteine residue {C49} cysteine residue {C75} MODIFICATION: cysteine residue {C59} Kazal-type serine protease inhibitor domain {115-157} MOTIF: cysteine residue {X+0} MODIFICATION: cysteine residue {X+X4} cysteine residue {X+X1} MODIFICATION: cysteine residue {X+X3} cysteine residue {X+X2} MODIFICATION: cysteine residue {X+X5} cysteine residue {X+X3} MODIFICATION: cysteine residue {X+X1} cysteine residue {X+X4} MODIFICATION: cysteine residue {X+0} cysteine residue {X+X5} MODIFICATION: cysteine residue {X+X2} cysteine residue {C116} MODIFICATION: cysteine residue {C146} cysteine residue {C120} MODIFICATION: cysteine residue {C139} Reactive bond {122-123} cysteine residue {C128} MODIFICATION: cysteine residue {C157} cysteine residue {C139} MODIFICATION: cysteine residue {C120} cysteine residue {C146} MODIFICATION: cysteine residue {C116} cysteine residue {C157} MODIFICATION: cysteine residue {C128} FOR-BINDING-OF: serine protease immunoglobulin superfamily domain {186-279} MOTIF: cysteine residue {C207} MODIFICATION: cysteine residue {C263} cysteine residue {C263} MODIFICATION: cysteine residue {C207} BPTI/Kunitz inhibitor 1 {299-351} MOTIF: cysteine residue {C299} MODIFICATION: cysteine residue {C351} cysteine residue {C306} MODIFICATION: cysteine residue {C334} cysteine residue {C326} MODIFICATION: cysteine residue {C347} cysteine residue {C334} MODIFICATION: cysteine residue {C306} cysteine residue {C347} MODIFICATION: cysteine residue {C326} cysteine residue {C351} MODIFICATION: cysteine residue {C299} BPTI/Kunitz inhibitor 2 {359-409} MOTIF: cysteine residue {C359} MODIFICATION: cysteine residue {C409} cysteine residue {C368} MODIFICATION: cysteine residue {C392} cysteine residue {C384} MODIFICATION: cysteine residue {C405} cysteine residue {C392} MODIFICATION: cysteine residue {C368} cysteine residue {C405} MODIFICATION: cysteine residue {C384} NTR {409-540} MOTIF: cysteine residue {C409} MODIFICATION: cysteine residue {C359} cysteine residue {C417} MODIFICATION: cysteine residue {C489} cysteine residue {C420} MODIFICATION: cysteine residue {C491} cysteine residue {C431} MODIFICATION: cysteine residue {C540} cysteine residue {C489} MODIFICATION: cysteine residue {C417} cysteine residue {C491} MODIFICATION: cysteine residue {C420} N-glycosylation site {N493} cysteine residue {C540} MODIFICATION: cysteine residue {C431}

Database Correlations

OMIM 608021 UniProt Q96NZ8 PFAM correlations

References

UniProt :accession Q96NZ8