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WAP four-disulfide core domain protein 12; protease inhibitor WAP12; whey acidic protein 2 (WFDC12, C20orf122, WAP2, UNQ544/PRO844)
Function:
- antibacterial protein
- putative acid-stable serine proteinase inhibitor
Structure: contains 1 WAP domain
Compartment: secreted
Alternative splicing: named isoforms=1
Expression:
- expressed in prostate, skin, lung, esophagus > skeletal muscle, epididymis, kidney, trachea, salivary gland, testis, seminal vesicle
General
WAP four-disulfide core domain protein
Properties
SIZE: MW = 12 kD
entity length = 111 aa
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-23}
WAP {30-74}
MOTIF: cysteine residue {C34}
MODIFICATION: cysteine residue {C62}
cysteine residue {C41}
MODIFICATION: cysteine residue {C66}
cysteine residue {C49}
MODIFICATION: cysteine residue {C61}
cysteine residue {C55}
MODIFICATION: cysteine residue {C70}
cysteine residue {C61}
MODIFICATION: cysteine residue {C49}
cysteine residue {C62}
MODIFICATION: cysteine residue {C34}
cysteine residue {C66}
MODIFICATION: cysteine residue {C41}
cysteine residue {C70}
MODIFICATION: cysteine residue {C55}
INHIBITS: serine protease
Database Correlations
UniProt Q8WWY7
Pfam PF00095
References
UniProt :accession Q8WWY7