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WAP four-disulfide core domain protein 1 (prostate stromal protein ps20, ps20 growth inhibitor, WFDC1, PS20)
Function:
- putative serine protease inhibitor
- growth inhibitory activity
Structure:
- contains 1 WAP domain
Compartment: secreted protein
General
WAP four-disulfide core domain protein
Properties
SIZE: MW = 24 kD
entity length = 220 aa
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-31}
WAP {62-108}
MOTIF: cysteine residue {C66}
MODIFICATION: cysteine residue {C96}
proline-rich region
SITE: 67-70
MOTIF: proline residue (SEVERAL)
cysteine residue {C78}
MODIFICATION: cysteine residue {C100}
cysteine residue {C83}
MODIFICATION: cysteine residue {C95}
cysteine residue {C89}
MODIFICATION: cysteine residue {C104}
cysteine residue {C95}
MODIFICATION: cysteine residue {C83}
cysteine residue {C96}
MODIFICATION: cysteine residue {C66}
cysteine residue {C100}
MODIFICATION: cysteine residue {C78}
cysteine residue {C104}
MODIFICATION: cysteine residue {C89}
proline-rich region
SITE: 109-112
MOTIF: proline residue (SEVERAL)
INHIBITS: serine protease
Database Correlations
OMIM 605322
UniProt Q9HC57
Pfam PF00095
References
- UniProt :accession Q9HC57
- Atlas of Genetics and Cytogenetics in Oncology and Haematology
http://atlasgeneticsoncology.org/Genes/WFDC1ID424.html