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WAP four-disulfide core domain protein
Function: family of serine protease inhibitors
Structure: contains WAP domain
Specific
WAP four-disulfide core domain protein 1 (prostate stromal protein ps20, ps20 growth inhibitor, WFDC1, PS20)
WAP four-disulfide core domain protein 10A precursor (protease inhibitor WAP10A, WFDC10A, C20orf146, WAP10)
WAP four-disulfide core domain protein 12; protease inhibitor WAP12; whey acidic protein 2 (WFDC12, C20orf122, WAP2, UNQ544/PRO844)
WAP four-disulfide core domain protein 2 (major epididymis-specific protein E4, epididymal secretory protein E4, protease inhibitor WAP5, WFDC2 HE4 WAP5)
WAP four-disulfide core domain protein 3 (protease inhibitor WAP14, WFDC3, WAP14)
WAP four-disulfide core domain protein 5 (protease inhibitor WAP1, p53-responsive gene 5 protein, WFDC5, PRG5, WAP1, NQ3036/PRO9842)
WAP four-disulfide core domain protein 6 (protease inhibitor WAP6, WFDC6, C20orf171, WAP6)
WAP four-disulfide core domain protein 7 (epididymal protease inhibitor, eppin, serine protease inhibitor-like with Kunitz & WAP domains 1, protease inhibitor WAP7, SPINLW1 WFDC7)
WAP four-disulfide core domain protein 8 precursor (protease inhibitor WAP8, WFDC8, C20orf170, WAP8)
General
secreted protein
serine protease inhibitor; serpin
Properties
COMPARTMENT: extracellular compartment
MOTIF: WAP {30-74}
MOTIF: cysteine residue {C34}
MODIFICATION: cysteine residue {C62}
cysteine residue {C41}
MODIFICATION: cysteine residue {C66}
cysteine residue {C49}
MODIFICATION: cysteine residue {C61}
cysteine residue {C55}
MODIFICATION: cysteine residue {C70}
cysteine residue {C61}
MODIFICATION: cysteine residue {C49}
cysteine residue {C62}
MODIFICATION: cysteine residue {C34}
cysteine residue {C66}
MODIFICATION: cysteine residue {C41}
cysteine residue {C70}
MODIFICATION: cysteine residue {C55}
INHIBITS: serine protease
References
- UniProt :accession Q9HC57
- UniProt :accession Q14508
- UniProt :accession Q8IUB2
- UniProt :accession Q8WWY7
- UniProt :accession Q8IUA0