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V-set & immunoglobulin domain-containing protein 1; cell surface A33 antigen; glycoprotein A34 (VSIG1, GPA34)
Structure:
- highly N-glycosylated
- appears not to contain significant amounts of O-linked carbohydrates or sialic acid in its sugar moieties
- contains 1 Ig-like C2-type domain (immunoglobulin-like)
- contains 1 Ig-like V-type domain (immunoglobulin-like)
Compartment: membrane
Expression:
- detected only in stomach mucosa & testis >> pancreas (at protein level)
Pathology:
- detected in gastric cancers (31%), esophageal carcinomas (50%) & ovarian cancers (23%)
Related
cell surface A33 antigen (glycoprotein A33, GPA33)
General
glycoprotein
membrane protein
V-set & immunoglobulin domain-containing protein (VSIG)
Properties
SIZE: entity length = 387 aa
MW = 42 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-21}
immunoglobulin superfamily domain {22-132}
MOTIF: N-glycosylation site {N32}
N-glycosylation site {N38}
cysteine residue {C43}
MODIFICATION: cysteine residue {C116}
cysteine residue {C116}
MODIFICATION: cysteine residue {C43}
N-glycosylation site {N133}
immunoglobulin superfamily domain {140-227}
MOTIF: cysteine residue {C161}
MODIFICATION: cysteine residue {C211}
N-glycosylation site {N200}
cysteine residue {C211}
MODIFICATION: cysteine residue {C161}
N-glycosylation site {N219}
transmembrane domain {233-253}
Database Correlations
UniProt Q86XK7
PFAM correlations
References
UniProt :accession Q86XK7