Search
von Willebrand factor C & EGF domain-containing protein (HBV X protein up-regulated gene 11 protein, HBxAg up-regulated gene 11 protein, VWCE, URG11)
Function:
- may be a regulatory element in the beta-catenin signaling pathway & a target for chemoprevention of hepatocellular carcinoma
Structure:
- contains 4 EGF-like domains
- contains 6 VWFC domains
Compartment: secreted (putative), cytoplasm ?
Alternative splicing: named isoforms=2
Expression:
- expressed in liver
- induced by HBxAg
General
glycoprotein
secreted protein
Properties
SIZE: entity length = 955 aa
MW = 100 kD
COMPARTMENT: cytoplasm
MOTIF: signal sequence {1-21}
EGF domain {70-98}
EGF domain {142-180}
MOTIF: cysteine residue {C146}
MODIFICATION: cysteine residue {C155}
cysteine residue {C151}
MODIFICATION: cysteine residue {C164}
cysteine residue {C155}
MODIFICATION: cysteine residue {C146}
cysteine residue {C164}
MODIFICATION: cysteine residue {C151}
cysteine residue {C166}
MODIFICATION: cysteine residue {C179}
cysteine residue {C179}
MODIFICATION: cysteine residue {C166}
EGF domain {181-219}
MOTIF: cysteine residue {C185}
MODIFICATION: cysteine residue {C194}
cysteine residue {C190}
MODIFICATION: cysteine residue {C203}
cysteine residue {C194}
MODIFICATION: cysteine residue {C185}
cysteine residue {C203}
MODIFICATION: cysteine residue {C190}
cysteine residue {C205}
MODIFICATION: cysteine residue {C218}
cysteine residue {C218}
MODIFICATION: cysteine residue {C205}
EGF domain {220-262}
MOTIF: cysteine residue {C224}
MODIFICATION: cysteine residue {C237}
cysteine residue {C233}
MODIFICATION: cysteine residue {C246}
cysteine residue {C237}
MODIFICATION: cysteine residue {C224}
cysteine residue {C246}
MODIFICATION: cysteine residue {C233}
cysteine residue {C248}
MODIFICATION: cysteine residue {C261}
cysteine residue {C261}
MODIFICATION: cysteine residue {C248}
VWFC domain {384-441}
VWFC domain {442-502}
MOTIF: N-glycosylation site {N462}
N-glycosylation site {N472}
VWFC domain {503-560}
VWFC domain {566-626}
VWFC domain {627-685}
VWFC domain {686-743}
proline-rich region
SITE: 835-872
MOTIF: proline residue (SEVERAL)
Database Correlations
UniProt Q96DN2
PFAM correlations
Kegg hsa:2200
References
UniProt :accession Q96DN2