von Willebrand factor A domain-containing protein 2 (A domain-containing protein similar to matrilin & collagen, AMACO, colon cancer secreted protein 2, CCSP-2, VWA2, AMACO)

Structure: - contains 2 EGF-like domains - contains 3 VWFA domains - forms monomers & multimers (putative) - 55 kD form is produced by proteolytic cleavage Compartment: secreted Alternative splicing: named isoforms=3 Expression: - expression is generally absent in normal colon & other normal body tissues Pathology: - induced an average of 78-fold in Stage II, III, & IV colon cancers, as well as in colon adenomas & colon cancer cell lines Note: serological marker for colon neoplasia

Properties

SIZE: entity length = 755 aa MW = 82 kD COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-23} VWFA domain {51-222} MOTIF: N-glycosylation site {N147} proteolytic site {267-268} EGF domain {296-333} MOTIF: cysteine residue {C299} MODIFICATION: cysteine residue {C310} cysteine residue {C304} MODIFICATION: cysteine residue {C320} cysteine residue {C310} MODIFICATION: cysteine residue {C299} cysteine residue {C320} MODIFICATION: cysteine residue {C304} cysteine residue {C322} MODIFICATION: cysteine residue {C332} cysteine residue {C332} MODIFICATION: cysteine residue {C322} VWFA domain {343-517} VWFA domain {531-705} EGF domain {712-748} MOTIF: cysteine residue {C716} MODIFICATION: cysteine residue {C727} cysteine residue {C721} MODIFICATION: cysteine residue {C736} cysteine residue {C727} MODIFICATION: cysteine residue {C716} cysteine residue {C736} MODIFICATION: cysteine residue {C721} cysteine residue {C738} MODIFICATION: cysteine residue {C747} cysteine residue {C747} MODIFICATION: cysteine residue {C738}

Database Correlations

UniProt Q5GFL6 PFAM correlations

References

UniProt :accession Q5GFL6