lipocalin-1; Von Ebner gland protein; VEG protein; tear prealbumin; TP; tear lipocalin; Tlc (LCN1, VEGP)

Function: - could play a role in taste reception - could be necessary for the concentration & delivery of sapid molecules in the gustatory system - can bind various ligands, with chemical structures ranging from lipids & retinoids to the macrocyclic antibiotic rifampicin & even to microbial siderophores. - exhibits an extremely wide ligand pocket - binds to LMBR1L which may mediate its endocytosis Structure: - homodimer (putative) - belongs to the calycin superfamily, lipocalin family Compartment: secreted Expression: - mainly expressed in lacrimal & salivary glands. - also expressed in the prostate

General

lipocalin secreted protein

Properties

SIZE: entity length = 176 aa MW = 19 kD COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-18} cysteine residue {C79} MODIFICATION: cysteine residue {C171} cysteine residue {C171} MODIFICATION: cysteine residue {C79}

Database Correlations

OMIM 151675 UniProt P31025 Pfam PF00061 Entrez Gene 3933 Kegg hsa:3933

References

UniProt :accession P31025