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voltage-gated K+ channel alpha subunit

Struture - four alpha subunits combine to form a functional voltage-gated K+ channel - between transmembrane domains 5 & 6 is an exoplasmic loop containing the pore-forming region (H5 region)

Specific

K+ voltage-gated channel subfamily A member 10 (voltage-gated K+ channel subunit Kv1.8, KCNA10) K+ voltage-gated channel subfamily A member 1; voltage-gated K+ channel subunit Kv1.1; HUKI; HBK1 (KCNA1) K+ voltage-gated channel subfamily A member 2; voltage-gated K+ channel subunit Kv1.2; HBK5; NGK1; HUKIV (KCNA2, RBK2, RCK5, MK2) K+ voltage-gated channel subfamily A member 3; voltage-gated K+ channel subunit Kv1.3; HPCN3; HGK5; HuKIII; HLK3 (KCNA3, HGK5) K+ voltage-gated channel subfamily A member 4 (voltage-gated K+ channel subunit Kv1.4, HK1, HPCN2, HBK4, HUKII, KCNA4, KCNA4L) K+ voltage-gated channel subfamily A member 5 (voltage-gated K+ channel subunit Kv1.5, HK2, HPCN1, KCNA5) K+ voltage-gated channel subfamily A member 6; voltage-gated K+ channel subunit Kv1.6; HBK2 (KCNA6)

General

ion channel subunit K+ channel oligomerizing protein phosphoprotein transmembrane 6 protein

Properties

COMPARTMENT: plasma membrane MOTIF: transmembrane domain (6) H5 (K+) pore-forming region ION-PERMEABILITY: K+

References

  1. Kubo Y, Baldwin TJ, Jan YN, Jan LY. Primary structure and functional expression of a mouse inward rectifier potassium channel. Nature. 1993 Mar 11;362(6416):127-33. PMID: 7680768
  2. Martens JR, Kwak YG, Tamkun MM. Modulation of Kv channel alpha/beta subunit interactions. Trends Cardiovasc Med. 1999 Nov;9(8):253-8. Review. PMID: 11094335

Component-of

voltage-gated K+ A channel (K+ channel IA , ISA, IA, A type K+ channel)