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voltage-dependent Ca+2 channel gamma-2 (neuronal voltage-gated calcium channel gamma-2 subunit, CACNG2)
Function:
- stabilizes voltage-dependent Ca+2 channel, L-type Ca+2 channel in an inactivated (closed) state
- interacts with the PDZ domains of DLG4/PSD-95 & DLG1/SAP97
- may interact with GOPC
- phosphorylation of Thr-321 impairs interaction with DLG1 & DLG4
Structure:
- belongs to the PMP-22/EMP/MP20 family, CACNG subfamily
Compartment: membrane
Expression: brain
General
glycoprotein
phosphoprotein
transmembrane 4 protein
voltage-dependent Ca+2 channel-gamma
Properties
SIZE: entity length = 323 aa
MW = 36 kD
MOTIF: transmembrane domain {10-30}
N-glycosylation site {N48}
transmembrane domain {104-124}
transmembrane domain {134-154}
transmembrane domain {182-202}
Ser phosphorylation site {S253}
Tyr phosphorylation site {Y271}
Thr phosphorylation site {T321}
Database Correlations
OMIM 602911
UniProt Q9Y698
Pfam PF00822
Entrez Gene 10369
Kegg hsa:10369
References
UniProt :accession Q9Y698