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voltage-dependent Ca+2 channel alpha-2/delta

The alpha-2 & delta subunits of the voltage-dependent Ca+2 channel are proteolytically processed from the same precursors (voltage-dependent Ca+2 channel alpha-2/delta); however, it is unclear whether cleavage really takes place in vivo & has a functional role

Specific

voltage-dependent Ca+2 channel alpha-2/delta-1 (L type, dihydropyridine-sensitive, CACNA2D1, CACNL2A, CCHL2A) Voltage-dependent Ca+2 channel subunit alpha-2/delta-2 (voltage-gated Ca+2 channel subunit alpha-2/delta-2, [Contains: Voltage-dependent Ca+2 channel subunit alpha-2-2; Voltage-dependent Ca+2 channel subunit delta-2], CACNA2D2, KIAA0558) Voltage-dependent Ca+2 channel subunit alpha-2/delta-3 (voltage-gated Ca+2 channel subunit alpha-2/delta-3, [Contains: Voltage-dependent Ca+2 channel subunit alpha-2-3; Voltage-dependent Ca+2 channel subunit delta-3], CACNA2D3) voltage-dependent Ca+2 channel subunit alpha-2/delta-4 (voltage-gated Ca+2 channel subunit alpha-2/delta-4, [Contains: Voltage-dependent Ca+2 channel subunit alpha-2-4; Voltage-dependent Ca+2 channel subunit delta-4], CACNA2D4)

General

glycoprotein voltage-dependent Ca+2 channel-alpha

Properties

COMPARTMENT: cellular membrane MOTIF: membrane region

References

  1. Williams ME et al Structure and functional expression of an omega-conotoxin- sensitive human N-type calcium channel. Science. 1992 Jul 17;257(5068):389-95. PMID: 1321501
  2. Witcher DR, De Waard M, Sakamoto J, Franzini-Armstrong C, Pragnell M, Kahl SD, Campbell KP. Subunit identification and reconstitution of the N-type Ca2+ channel complex purified from brain. Science. 1993 Jul 23;261(5120):486-9. PMID: 8392754
  3. Campbell KP et al The biochemistry and molecular biology of the dihydropyridine-sensitive calcium channel. TINS 11:425 1988 PMID: 2469159

Component-of

L-type Ca+2 channel, long duration or slowly inactivating Ca+2 channel or dihydropyridine receptor (R-type Ca+2 channel)