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voltage-dependent Ca+2 channel
Function:
- voltage-sensitive Ca+2 channels (VSCC) mediate the entry of Ca+2 into excitable cells
- roles in a variety of Ca+2-dependent processes, including
a) muscle contraction
b) hormone or neurotransmitter release
c) gene expression
d) cell motility
e) cell division
f) cell death
Structure:
- multisubunit complexes, consisting of alpha-1 (CACNA1), alpha-2-delta (CACNA2D), beta (CACNB) subunits in a 1:1:1 ratio
- alpha-2-delta transcribed from a single gene; unclear if protein is cleave into separate alpha-2 & delta subunits
- L-type Ca+2 channels also contain a gamma subunit
- the channel activity is directed by the pore-forming & voltage-sensitive alpha-1 subunit
- in many cases, the alpha-1 subunit is sufficient to generate voltage-sensitive Ca+2 channel activity
- the auxiliary subunits beta & alpha-2/delta linked by a disulfide bridge regulate channel activity
Specific
cation channel sperm-associated protein 2 (Catsper2, CATSPER2)
L-type Ca+2 channel, long duration or slowly inactivating Ca+2 channel or dihydropyridine receptor (R-type Ca+2 channel)
N-type Ca+2 channel or neuronal-type Ca+2 channel
NMDA receptor
P-type Ca+2 channel or Purkinje cell Ca+2 channel
T-type Ca+2 channel or transient current Ca+2 channel
General
Ca+2 channel
multisubunit protein
plasma membrane protein
voltage-gated ion channel
Properties
COMPARTMENT: cellular membrane
MOTIF: membrane region
ion channel
COMPARTMENT: cellular membrane
MOTIF: membrane region
ION-PERMEABILITY: Ca+2
SUBUNITS: voltage-dependent Ca+2 channel alpha-1
MOTIF: cytoplasmic domain {N-TERMINAL}
exoplasmic loop
LOOP#: 1
exoplasmic loop
LOOP#: 2
exoplasmic loop
LOOP#: 3
exoplasmic loop
LOOP#: 4
exoplasmic loop
LOOP#: 5
exoplasmic loop
LOOP#: 6
exoplasmic loop
LOOP#: 7
exoplasmic loop
LOOP#: 8
exoplasmic loop
LOOP#: 9
exoplasmic loop
LOOP#: 10
exoplasmic loop
LOOP#: 11
exoplasmic loop
LOOP#: 12
glycosylation site
membrane channel
phosphorylation site
cytoplasmic domain {C-TERMINAL}
voltage-dependent Ca+2 channel alpha-2/delta
MOTIF: membrane region
voltage-dependent Ca+2 channel beta
MOTIF: membrane region
Ca+2 channel-gamma
References
UniProt :accession Q8IZS8
Components
voltage-dependent Ca+2 channel alpha-1
voltage-dependent Ca+2 channel alpha-2/delta
voltage-dependent Ca+2 channel beta
voltage-dependent Ca+2 channel-gamma