Contents

Search

very low-density lipoprotein receptor; VLDL receptor; VLDL-R (VLDLR)

Function: - binds VLDL & transports it into cells by endocytosis - receptor-ligand complexes cluster into clathrin-coated pits prior to endocytosis - binding to Reelin induces Tyr phosphorylation of Dab1 & modulation of Tau phosphorylation (putative) - binds to the extracellular matrix protein Reelin - interacts with VLDLR - interacts with SNX17 (putative) - interacts with DAB1 - receptor for the minor-group human rhinoviruses (HRVs) - binds protein VP1 through the 2nd & 3rd LDL-receptor class A domains - VLDL receptor binds apolipoprotein E Structure: - contains 3 EGF-like domains - contains 8 LDL-receptor class A domains - contains 6 LDL-receptor class B repeats Compartment: - membrane - clathrin-coated pit Alternative splicing: named isoforms=2 Expression: - abundant in heart & skeletal muscle - also expressed in ovary & kidney - tissue distribution of the VLDL receptor is very different from the LDL receptor - mRNA for the VLDL receptor is abundant in cells with active fatty acid metabolism, including heart, muscle & adipose tissue - very little is expressed in liver. Pathology: - deletions involving VLDLR may be the cause of VLDLR-associated cerebellar hypoplasia

Related

very low-density lipoprotein [VLDL] receptor gene

General

glycoprotein lipoprotein receptor

Properties

SIZE: entity length = 873 aa MW = 96 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-27} LDL-receptor class A {31-69} MOTIF: cysteine residue {C33} MODIFICATION: cysteine residue {C45} cysteine residue {C40} MODIFICATION: cysteine residue {C58} cysteine residue {C45} MODIFICATION: cysteine residue {C33} cysteine residue {C52} MODIFICATION: cysteine residue {C67} cysteine residue {C58} MODIFICATION: cysteine residue {C40} cysteine residue {C67} MODIFICATION: cysteine residue {C52} LDL-receptor class A {70-110} MOTIF: cysteine residue {C72} MODIFICATION: cysteine residue {C84} cysteine residue {C79} MODIFICATION: cysteine residue {C97} cysteine residue {C84} MODIFICATION: cysteine residue {C72} cysteine residue {C91} MODIFICATION: cysteine residue {C108} cysteine residue {C97} MODIFICATION: cysteine residue {C79} cysteine residue {C108} MODIFICATION: cysteine residue {C91} LDL-receptor class A {111-151} MOTIF: cysteine residue {C113} MODIFICATION: cysteine residue {C127} cysteine residue {C120} MODIFICATION: cysteine residue {C140} cysteine residue {C127} MODIFICATION: cysteine residue {C113} cysteine residue {C134} MODIFICATION: cysteine residue {C149} cysteine residue {C140} MODIFICATION: cysteine residue {C120} cysteine residue {C149} MODIFICATION: cysteine residue {C134} N-glycosylation site {N151} LDL-receptor class A {152-190} MOTIF: cysteine residue {C154} MODIFICATION: cysteine residue {C166} cysteine residue {C161} MODIFICATION: cysteine residue {C179} cysteine residue {C166} MODIFICATION: cysteine residue {C154} cysteine residue {C173} MODIFICATION: cysteine residue {C188} cysteine residue {C179} MODIFICATION: cysteine residue {C161} cysteine residue {C188} MODIFICATION: cysteine residue {C173} LDL-receptor class A {191-231} MOTIF: cysteine residue {C193} MODIFICATION: cysteine residue {C205} cysteine residue {C200} MODIFICATION: cysteine residue {C218} cysteine residue {C205} MODIFICATION: cysteine residue {C193} cysteine residue {C212} MODIFICATION: cysteine residue {C229} cysteine residue {C218} MODIFICATION: cysteine residue {C200} cysteine residue {C229} MODIFICATION: cysteine residue {C212} LDL-receptor class A {237-275} MOTIF: cysteine residue {C239} MODIFICATION: cysteine residue {C251} cysteine residue {C246} MODIFICATION: cysteine residue {C264} cysteine residue {C251} MODIFICATION: cysteine residue {C239} cysteine residue {C258} MODIFICATION: cysteine residue {C273} cysteine residue {C264} MODIFICATION: cysteine residue {C246} cysteine residue {C273} MODIFICATION: cysteine residue {C258} LDL-receptor class A {276-314} MOTIF: cysteine residue {C278} MODIFICATION: cysteine residue {C290} cysteine residue {C285} MODIFICATION: cysteine residue {C303} cysteine residue {C290} MODIFICATION: cysteine residue {C278} cysteine residue {C297} MODIFICATION: cysteine residue {C312} cysteine residue {C303} MODIFICATION: cysteine residue {C285} cysteine residue {C312} MODIFICATION: cysteine residue {C297} LDL-receptor class A {316-355} MOTIF: cysteine residue {C318} MODIFICATION: cysteine residue {C331} cysteine residue {C326} MODIFICATION: cysteine residue {C344} cysteine residue {C331} MODIFICATION: cysteine residue {C318} cysteine residue {C338} MODIFICATION: cysteine residue {C355} cysteine residue {C344} MODIFICATION: cysteine residue {C326} cysteine residue {C355} MODIFICATION: cysteine residue {C338} EGF domain {356-395} MOTIF: cysteine residue {C360} MODIFICATION: cysteine residue {C371} cysteine residue {C367} MODIFICATION: cysteine residue {C380} cysteine residue {C371} MODIFICATION: cysteine residue {C360} cysteine residue {C380} MODIFICATION: cysteine residue {C367} cysteine residue {C382} MODIFICATION: cysteine residue {C394} cysteine residue {C394} MODIFICATION: cysteine residue {C382} EGF domain {396-435} MOTIF: cysteine residue {C400} MODIFICATION: cysteine residue {C410} cysteine residue {C406} MODIFICATION: cysteine residue {C419} cysteine residue {C410} MODIFICATION: cysteine residue {C400} cysteine residue {C419} MODIFICATION: cysteine residue {C406} cysteine residue {C421} MODIFICATION: cysteine residue {C434} cysteine residue {C434} MODIFICATION: cysteine residue {C421} LDL-receptor class B {439-480} LDL-receptor class B {481-524} LDL-receptor class B {525-567} LDL-receptor class B {568-611} LDL-receptor class B {612-654} LDL-receptor class B {655-697} EGF domain {702-750} MOTIF: cysteine residue {C706} MODIFICATION: cysteine residue {C719} cysteine residue {C715} MODIFICATION: cysteine residue {C734} cysteine residue {C719} MODIFICATION: cysteine residue {C706} cysteine residue {C734} MODIFICATION: cysteine residue {C715} cysteine residue {C736} MODIFICATION: cysteine residue {C749} cysteine residue {C749} MODIFICATION: cysteine residue {C736} domain {751-790} MOTIF: N-glycosylation site {N765} N-glycosylation site {N781} transmembrane domain {798-819} Endocytosis signal {832-837} MISC-INFO: LIGAND = APOLIPOPROTEIN_E

Database Correlations

OMIM correlations UniProt P98155 PFAM correlations Entrez Gene 7436 Kegg hsa:7436

References

  1. Sakai J et al Structure, chromosome location, and expression of the human very low density lipoprotein receptor gene. J Biol Chem. 1994 Jan 21;269(3):2173-82. PMID: 8294473
  2. UniProt :accession P98155
  3. SeattleSNPs http://pga.gs.washington.edu/data/vldlr/