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vitronectin; S-protein; serum-spreading factor; V75; contains: vitronectin V65 subunit; vitronectin V10 subunit; somatomedin-B (VTN)
Function:
- cell adhesion & spreading factor in plasma & tissues.
- interaction with glycosaminoglycans & proteoglycans
- recognized by some integrins
- inhibitor of the membrane-damaging effect of the terminal
- interacts with SERPINE1/PAI1 & insulin cytolytic complement pathway
- phosphorylation on Thr-69 & Thr-76 favors cell adhesion & spreadings
- precursor for somatomedin B
Structure:
- exists in two forms: a single chain 75 kD form (V75) & a clipped form composed of two chains (65 kD & 10 kD) (V65+V10) which are held together by a disulfide bond
- sulfated on 2 Tyr, N- & O-glycosylated (putative)
- SMB domain may have disulfide bond heterogeneity
- SMB domain mediates interaction with SERPINE1/PAI1
- heparin-binding domain mediates interaction with insulin
- contains 4 hemopexin-like domains
- contains 1 SMB (somatomedin-B) domain
Compartment: secreted, extracellular space
Expression: plasma
Interactions
molecular events
Related
glycoprotein IIB/IIIA
vitronectin receptor
General
cell adhesion protein
glycoprotein
matrix protein
peptide precursor
Properties
SIZE: MW = 54 kD
entity length = 478 aa
COMPARTMENT: extracellular matrix
MOTIF: signal sequence {1-19}
somatomedin B domain {20-63}
MOTIF: cysteine residue {C24}
MODIFICATION: cysteine residue {C28}
cysteine residue {C28}
MODIFICATION: cysteine residue {C24}
cysteine residue {C38}
MODIFICATION: cysteine residue {C40}
cysteine residue {C40}
MODIFICATION: cysteine residue {C38}
cysteine residue {C44}
MODIFICATION: cysteine residue {C50}
cysteine residue {C50}
MODIFICATION: cysteine residue {C44}
cysteine residue {C51}
MODIFICATION: cysteine residue {C58}
cysteine residue {C58}
MODIFICATION: cysteine residue {C51}
N-glycosylation site {N86}
HEMOPEXIN-LIKE 1 {150-287}
MOTIF: N-glycosylation site {N169}
N-glycosylation site {N242}
HEMOPEXIN-LIKE 2 {288-478}
MOTIF: cysteine residue {C293}
MODIFICATION: cysteine residue {C430}
binding site
SITE: 362-395
FOR-BINDING-OF: heparin
Ser phosphorylation site {S397}
FOR-PHOSPHORYLATION-BY: protein kinase A
proteolytic site {398-399}
cysteine residue {C430}
MODIFICATION: cysteine residue {C293}
Database Correlations
OMIM 193190
UniProt P04004
PFAM correlations
Entrez Gene 7448
Kegg hsa:7448
References
- Entrez Gene :accession 7448
- UniProt :accession P04004
- SeattleSNPs
http://pga.gs.washington.edu/data/vtn/
Component-of
complement complex