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visual pigment-like receptor peropsin (rhodopsin homolog retinal pigment epithelium-derived, RRH, rhodopsin homolog RPE-derived)
Function:
- may play a role in retinal pigment epithelium physiology either by detecting light directly or by monitoring the concentration of retinoids or other photoreceptor-derived compounds
Structure:
- belongs to the G-protein coupled receptor 1 family opsin subfamily
Compartment: membrane
Expression:
- found only in the eye, localized to the retinal pigment epithelium
- in the retinal pigment epithelium, localized to microvilli that surround the photoreceptor outer segments
General
glycoprotein
G-protein coupled receptor; serpentine receptor
Properties
SIZE: MW = 37 kD
entity length = 337 aa
COMPARTMENT: plasma membrane
MOTIF: transmembrane domain {TM1}
transmembrane domain {TM2}
transmembrane domain {TM3}
transmembrane domain {TM4}
transmembrane domain {TM5}
transmembrane domain {TM6}
transmembrane domain {TM7}
exoplasmic domain {1-26}
MOTIF: N-glycosylation site {N8}
transmembrane domain {27-49}
transmembrane domain {62-87}
exoplasmic domain {N-TERMINAL}
exoplasmic loop {88-101}
MOTIF: cysteine residue {C98}
MODIFICATION: cysteine residue {C175}
transmembrane domain {102-121}
transmembrane domain {141-164}
exoplasmic loop {165-188}
MOTIF: cysteine residue {C175}
MODIFICATION: cysteine residue {C98}
exoplasmic loop {266-272}
binding site
SITE: C-TERMINAL-CYS
EFFECTOR-BOUND: palmitate
BOUND-VIA: carboxylate
cytoplasmic loop {50-61}
cytoplasmic loop {122-140}
transmembrane domain {189-212}
cytoplasmic loop {213-240}
transmembrane domain {241-264}
cytoplasmic domain {C-TERMINAL}
transmembrane domain {273-297}
MOTIF: binding site
SITE: 284-284
FOR-BINDING-OF: retina
cytoplasmic domain {298-337}
Database Correlations
OMIM 605224
UniProt O14718
Pfam PF00001
Kegg hsa:1069
References
UniProt :accession O14718