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viral hemorrhagic fever syndrome; hemorrhagic nephroso-nephritis

Etiology: 1) arboviruses 2) arenaviruses - Whitewater Arroyo virus 3) Marburg virus 4) Ebola virus 5) Hantavirus 6) Crimean Congo hemorrhagic fever virus Epidemiology: - residence in or travel to endemic area - viruses reside in animal reservoirs Clinical manifestations: 1) symptoms appear 2-21 days after exposure [2] 2) triad of fever, shock & GI hemorrhage from GI mucosa of GI tract - abdominal pain, diarrhea 3) petechial rash, easy bruising 4) myalgia, weakness, fatigue, headache 5) multi-organ failure 6) shock Laboratory: - see individual viruses for laboratory diagnosis Management: - treatment is supportive - isolation of patients to prevent person to person transmission - notify health department

Related

arbovirus arenavirus

Specific

arenavirus-associated viral hemorrhagic fever syndrome Argentine hemorrhagic fever; O'Higgins disease; stubble disease Crimean-Congo hemorrhagic fever (CCHF) Ebola hemorrhagic fever hantavirus pulmonary syndrome Kyasanur forest disease (Monkey fever)

General

fever syndrome viral infection

References

  1. Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 96
  2. Medical Knowledge Self Assessment Program (MKSAP) 15, 17, 18, 19. American College of Physicians, Philadelphia 2009, 2015, 2018, 2021