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VIP36-like protein; lectin mannose-binding 2-like; LMAN2-like protein (LMAN2L, VIPL, PSEC0028, UNQ368/PRO704)
Function:
- may be involved in the regulation of export from the endoplasmic reticulum of a subset of glycoproteins
- may function as a regulator of ERGIC53
Structure:
- contains 1 L-type lectin-like domain
Compartment:
- endoplasmic reticulum membrane, Golgi membrane
- single-pass type 1 membrane protein
- predominantly found in the endoplasmic reticulum
Alternative splicing: named isoforms=2
Expression:
- expressed in numerous tissues
- expressed in skeletal muscle & kidney > heart, liver & placenta, low levels in > brain, thymus, spleen, small intestine & lung
General
Ca+2 binding protein
glycoprotein
membrane protein
Properties
SIZE: entity length = 348 aa
MW = 40 kD
COMPARTMENT: golgi
endoplasmic reticulum
MOTIF: signal sequence {1-44}
L-type lectin-like {49-274}
MOTIF: binding site
SITE: 93-93
FOR-BINDING-OF: Carbohydrate
binding site
SITE: 128-128
FOR-BINDING-OF: Carbohydrate
Ca+2-binding site
SITE: 159-159
Carbohydrate binding {161-163}
Ca+2-binding site
SITE: 161-161
Ca+2-binding site
SITE: 163-163
N-glycosylation site {N181}
binding site
SITE: 188-188
FOR-BINDING-OF: Carbohydrate
Ca+2-binding site
SITE: 191-191
cysteine residue {C200}
MODIFICATION: cysteine residue {C237}
cysteine residue {C237}
MODIFICATION: cysteine residue {C200}
Carbohydrate binding {258-260}
transmembrane domain {314-336}
Endoplasmic reticulum retention signal {344-346}
Database Correlations
OMIM 609552
UniProt Q9H0V9
Pfam PF03388
Entrez Gene 81562
Kegg hsa:81562
References
UniProt :accession Q9H0V9