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villin headpiece domain (VHP, HP)

Function: - modular motif found at the extreme C terminus of larger core domains in > 25 cytoskeletal proteins in plants & animals, often in assocation with the gelsolin repeat - F-actin-binding domain - not all headpiece domains - surface charge distribution may be an important element for F-actin recognition - autonomously folding domain Structure: - 76 amino acid residues

General

domain peptide motif

References

  1. Pfam :accession PF02209
  2. InterPro: IPR003128