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villin-1 (VIL1 VIL)
Function:
- Ca+2-regulated actin-binding protein
Structure:
- monomer
- consists of a large core fragment, the N-terminal portion, & a small headpiece, the C-terminal portion
- the headpiece binds F-actin strongly in both the presence & absence of Ca+2
- belongs to the villin/gelsolin family
- contains 6 gelsolin-like repeats
- contains 1 HP (headpiece) domain
Compartment: cytoplasm, cytoskeleton
Expression:
- major component of microvilli of intestinal epithelial cells & kidney proximal tubule cells
General
villin
Properties
SIZE: entity length = 827 aa
MW = 93 kD
COMPARTMENT: cytoplasm
MOTIF: Core {2-734}
MOTIF: domain {2-126}
Gelsolin-like {27-76}
binding site
SITE: 112-119
FOR-BINDING-OF: LPA/PIP2
binding site
SITE: 138-146
FOR-BINDING-OF: LPA/PIP2
Gelsolin-like {148-188}
Gelsolin-like {265-309}
Gelsolin-like {407-457}
Gelsolin-like {528-568}
Gelsolin-like {631-672}
Ca+2-binding site
binding site (2)
FOR-BINDING-OF: F-actin
Headpiece {735-827}
MOTIF: villin headpiece domain {761-827}
binding site
SITE: 816-824
FOR-BINDING-OF: LPA/PIP2
Database Correlations
OMIM 193040
UniProt P09327
PFAM correlations
Entrez Gene 7429
Kegg hsa:7429
References
- UniProt :accession P09327
- Entrez Gene :accession 7429