vigilin; high density lipoprotein-binding protein; HDL-binding protein (HDLBP HBP VGL)

Plays a role in cell sterol metabolism. May function to protect cells from over-accumulation of cholesterol. Function: - appears to play a role in cell sterol metabolism - may function to protect cells from over-accumulation of cholesterol Structure: contains 14 KH domains Compartment: cytoplasm, nucleus

General

nuclear protein phosphoprotein

Properties

SIZE: entity length = 1268 aa MW = 141 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Ser phosphorylation site {S31} KH domain SITE: 158-229 FOR-BINDING-OF: ribonucleic acid KH domain SITE: 230-302 FOR-BINDING-OF: ribonucleic acid MOTIF: Thr phosphorylation site {T295} Thr phosphorylation site {T296} KH domain SITE: 303-371 FOR-BINDING-OF: ribonucleic acid KH domain SITE: 372-442 FOR-BINDING-OF: ribonucleic acid MOTIF: Tyr phosphorylation site {Y437} KH domain SITE: 443-514 FOR-BINDING-OF: ribonucleic acid KH domain SITE: 515-588 FOR-BINDING-OF: ribonucleic acid KH domain SITE: 589-660 FOR-BINDING-OF: ribonucleic acid KH domain SITE: 661-734 FOR-BINDING-OF: ribonucleic acid KH domain SITE: 735-807 FOR-BINDING-OF: ribonucleic acid KH domain SITE: 808-880 FOR-BINDING-OF: ribonucleic acid KH domain SITE: 881-979 FOR-BINDING-OF: ribonucleic acid MOTIF: Ser phosphorylation site {S944} KH domain SITE: 980-1059 FOR-BINDING-OF: ribonucleic acid KH domain SITE: 1060-1134 FOR-BINDING-OF: ribonucleic acid KH domain SITE: 1135-1209 FOR-BINDING-OF: ribonucleic acid Ser phosphorylation site {S1223}

Database Correlations

OMIM 142695 UniProt Q00341 Pfam PF00013 Entrez Gene 3069

References

UniProt :accession Q00341