Search
vesicular integral-membrane protein VIP36; glycoprotein GP36b; lectin mannose-binding 2; vesicular integral-membrane protein 36; VIP36 (LMAN2, C5orf8)
Function:
- intracellular lectin in the early secretory pathway
- role in transport & sorting of glycoproteins carrying high mannose-type glycans
- interacts with:
a) N-acetyl-D-galactosamine
b) high-mannose glycans
c) O-linked glycans (possibly)
Cofactor: binds 2 Ca+2 per subunit
Structure:
- contains 1 L-type lectin-like domain
Compartment:
- endoplasmic reticulum, Golgi
- type 1 membrane protein
Expression: ubiquitous
General
Ca+2 binding protein
glycoprotein
membrane protein
Properties
SIZE: entity length = 356 aa
MW = 40 kD
COMPARTMENT: golgi
endoplasmic reticulum
MOTIF: signal sequence {1-44}
L-type lectin-like {52-276}
MOTIF: binding site
SITE: 96-96
FOR-BINDING-OF: Carbohydrate
binding site
SITE: 131-131
FOR-BINDING-OF: Carbohydrate
Ca+2-binding site
SITE: 162-162
Carbohydrate binding {164-166}
Ca+2-binding site
SITE: 164-164
Ca+2-binding site
SITE: 166-166
N-glycosylation site {N183}
binding site
SITE: 190-190
FOR-BINDING-OF: Carbohydrate
Ca+2-binding site
SITE: 193-193
cysteine residue {C202}
MODIFICATION: cysteine residue {C239}
cysteine residue {C239}
MODIFICATION: cysteine residue {C202}
Carbohydrate binding {260-262}
transmembrane domain {323-345}
Database Correlations
OMIM 609551
UniProt Q12907
Pfam PF03388
Entrez Gene 10960
Kegg hsa:10960
References
UniProt :accession Q12907