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vesicular glutamate transporter 3 (VGluT3, solute carrier family 17 member 8, SLC17A8, VGLUT3)
Function:
- mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells
- may also mediate the transport of inorganic phosphate
Structure:
- belongs to the major facilitator superfamily Na+/anion cotransporter family, VGLUT subfamily
Compartment:
- cytoplasmic vesicle, secretory vesicle,
- synaptic vesicle membrane (putative)
Alternative splicing: named isoforms=2
Expression:
- expressed in amygdala, cerebellum, hippocampus, medulla, spinal cord & thalamus
General
glycoprotein
solute carrier family 17 (SLC17, SLC17A)
transmembrane 12 protein
Properties
SIZE: entity length = 589 aa
MW = 65 kD
COMPARTMENT: cytoplasm
MOTIF: cytoplasmic domain {1-76}
transmembrane domain {77-97}
Vesicular {98-130}
MOTIF: exoplasmic loop {98-130}
N-glycosylation site {N106}
transmembrane domain {131-151}
cytoplasmic loop {152-153}
transmembrane domain {154-174}
Vesicular {175-182}
MOTIF: exoplasmic loop {175-182}
transmembrane domain {183-203}
cytoplasmic loop {204-221}
transmembrane domain {222-242}
Vesicular {243-249}
MOTIF: exoplasmic loop {243-249}
transmembrane domain {250-270}
cytoplasmic loop {271-314}
transmembrane domain {315-335}
Vesicular {336-353}
MOTIF: exoplasmic loop {336-353}
transmembrane domain {354-374}
cytoplasmic loop {375-390}
transmembrane domain {391-411}
Vesicular {412-413}
MOTIF: exoplasmic loop {412-413}
transmembrane domain {414-434}
cytoplasmic loop {435-447}
transmembrane domain {448-468}
Vesicular {469-481}
MOTIF: exoplasmic loop {469-481}
transmembrane domain {482-502}
cytoplasmic domain {503-586}
Database Correlations
OMIM 607557
MORBIDMAP 607557
UniProt Q8NDX2
Pfam PF07690
Kegg hsa:2462
References
UniProt :accession Q8NDX2