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vesicular glutamate transporter 2 (VGluT2, solute carrier family 17 member 6, differentiation-associated Na+-dependent inorganic phosphate cotransporter, differentiation-associated BNPI, SLC17A6, DNPI, VGLUT2)
Function:
- mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells
- may also mediate the transport of inorganic phosphate
Structure:
- belongs to the major facilitator superfamily Na+/anion cotransporter family. VGLUT subfamily
Compartment:
- cytoplasmic vesicle, secretory vesicle,
- synaptic vesicle membrane (putative)
Expression:
- predominantly expressed in adult brain
- expressed in fetal brain
General
glycoprotein
major facilitator superfamily (MFS)
solute carrier family 17 (SLC17, SLC17A)
transmembrane 12 protein
Properties
SIZE: entity length = 582 aa
MW = 64 kD
COMPARTMENT: cytoplasm
MOTIF: cytoplasmic domain {1-71}
transmembrane domain {72-92}
exoplasmic loop {93-125}
MOTIF: N-glycosylation site {N100}
N-glycosylation site {N101}
transmembrane domain {126-146}
cytoplasmic loop {147-148}
transmembrane domain {149-169}
exoplasmic loop {170-177}
transmembrane domain {178-198}
cytoplasmic loop {199-216}
transmembrane domain {217-237}
exoplasmic loop {238-244}
transmembrane domain {245-265}
cytoplasmic loop {266-310}
transmembrane domain {311-331}
exoplasmic loop {332-349}
transmembrane domain {350-370}
cytoplasmic loop {371-386}
transmembrane domain {387-407}
exoplasmic loop {408-409}
transmembrane domain {410-430}
cytoplasmic loop {431-443}
transmembrane domain {444-464}
exoplasmic loop {465-477}
MOTIF: N-glycosylation site {N470}
transmembrane domain {478-498}
cytoplasmic domain {499-582}
Database Correlations
OMIM 607563
UniProt Q9P2U8
Pfam PF07690
Kegg hsa:5708
References
UniProt :accession Q9P2U8