vesicle transport through interaction with t-SNAREs homolog 1B (vesicle transport v-SNARE protein Vti1-like 1, Vti1-rp1, VTI1B, VTI1, VTI1L, VTI1L1, VTI2)

Function: 1) v-SNARE 2) mediates vesicle transport pathways through interactions with t-SNAREs on target membrane 3) specificity of vesicle trafficking 4) fusion of the lipid bilayer 5) secretion of cytokines associated with cellular senescence 6) component of complex with VAMP8 & STX7 in liver 7) forms SNARE complex with STX7, STX8 & VAMP8 - homotypic fusion of late endosomes 8) component of SNARE core complex containing STX7, STX8 & VAMP8 Compartment: - intracytoplasmic membrane, cytoplasmic granule Alternative splicing: named isoforms=2 Expression: ubiquitous

Properties

SIZE: MW = 27 kD entity length = 232 aa COMPARTMENT: cytoplasm MOTIF: ligand-binding site SNARE motif {35-98} coiled coil {161-198} transmembrane domain {209-229} VESICULAR {230-232}

Database Correlations

OMIM 603207 UniProt Q9UEU0 Pfam PF05008

References

UniProt :accession Q9UEU0