vesicle transport protein SEC20 (BCL2/adenovirus E1B 19 kD protein-interacting protein 1, transformation-related gene 8 protein, TRG-8, BNIP1, NIP1, SEC20L, TRG8)

Function: 1) SNARE protein 2) targeting & fusion of Golgi-derived retrograde transport vesicles with the ER 3) maintenance of ER network - silencing of BNIP1 disrupts ER morphology 4) suppression of cell death 5) component of a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L & SEC22B 5) interacts directly with STX18, RINT1/TIP20L & NAPA 6) interacts with ZW10 through RINT1 7) interacts with BCL2 & adenovirus E1B 19 kD protein Compartment: endoplasmic reticulum Alternative splicing: named isoforms=4 Expression: - isoform 1 expressed in heart, brain, liver, skeletal muscle, pancreas - isoform 3 expressed in placenta, lung, kidney - isoform 4 expressed in testis, small intestine

Related

adenovirus oncoprotein E1b B-cell leukemia-2 (bcl-2) protein

Properties

SIZE: MW = 26 kD entity length = 228 aa COMPARTMENT: endoplasmic reticulum MOTIF: ligand-binding site SNARE motif {37-90} transmembrane domain {200-220}

Database Correlations

OMIM 603291 UniProt Q12981 Pfam PF03908

References

UniProt :accession Q12981