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vesicle-trafficking protein SEC22b; SEC22 vesicle-trafficking protein homolog B; SEC22 vesicle-trafficking protein-like 1 (ERS24, ERS-24, SEC22B, SEC22L1)
Function:
1) v-SNARE
a) targeting & fusion of ER-derived transport vesicles with Golgi, &
b) targeting & fusion of Golgi-derived retrograde transport vesicles with the ER
2) component of 2 distinct SNARE complexes consisting of
a) STX5, GOSR2/BOS1, BET1 and SEC22B or
b) STX18, USE1L, BNIP1/SEC20L
c) YKT6 can likely replace SEC22B in either complex
Compartment: endoplasmic reticulum-Golgi intermediate compartment
General
SNARE [soluble NSF attachment receptor] protein (SNARE, SNAP receptor)
Properties
SIZE: MW = 25 kD
entity length = 214 aa
COMPARTMENT: golgi
endoplasmic reticulum
MOTIF: ligand-binding site
LONGIN {5-118}
SNARE motif {133-193}
transmembrane domain {194-214}
Database Correlations
OMIM 604029
UniProt O75396
Pfam PF00957
References
UniProt :accession O75396