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vesicle-associated membrane protein 8 (VAMP-8, endobrevin, EDB, VAMP8)
Function:
1) targeting &/or fusion of transport vesicles to their target membrane
2) dense-granule secretion in platelets
3) regulated enzyme secretion in pancreatic acinar cells
4) abscission of the midbody during cell division,
5) homotypic fusion of early & late endosomes
6) found in a number of SNARE complexes with NAPA, SNAP23, SNAP25, STX1A, STX4, STX7, STX8 & VTI1B
7) interacts with STX8
Compartment: membrane
Expression: platelets
General
SNARE [soluble NSF attachment receptor] protein (SNARE, SNAP receptor)
Properties
SIZE: MW = 11 kD
entity length = 100 aa
COMPARTMENT: intracellular vesicle
MOTIF: ligand-binding site
SNARE motif {12-72}
transmembrane domain {76-96}
VESICULAR {97-100}
Database Correlations
OMIM 603177
UniProt Q9BV40
Pfam PF00957
References
UniProt :accession Q9BV40