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vesicle-associated membrane protein 4 (VAMP-4, VAMP4)
Function:
1) involved in pathway removes an inhibitor* of Ca+2-triggered exocytosis during maturation of secretory granules
2) component of sorting pathway critical for remodeling the secretory response of granule
* probably synaptotagmin-4
Structure:
1) belongs to the synaptobrevin family
2) contains 1 v-SNARE coiled-coil homology domain Golgi, trans-Golgi network & newly formed immature secretory granules, not found on the mature secretory organelles
Alternative splicing: named isoforms=2
General
phosphoprotein
SNARE [soluble NSF attachment receptor] protein (SNARE, SNAP receptor)
Properties
SIZE: MW = 16 kD
entity length = 141 aa
COMPARTMENT: golgi
MOTIF: Ser phosphorylation site {S30}
SNARE motif {52-112}
transmembrane domain {116-136}
VESICULAR {137-141}
Database Correlations
OMIM 606909
UniProt O75379
Pfam PF00957
References
UniProt :accession O75379