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velpatasvir
Indications:
- used in combination with sofosbuvir for treatment of hepatitis C infection
Dosage:
- combination with sofosbuvir PO QD
Mechanism of action:
- NS5A inhibitor
General
carbamate
heterocyclic compound, 4 or more rings
NS5A inhibitor
Database Correlations
PUBCHEM cid=67683363
References
- Orciari Herman A, Fairchild DG]
New Once-Daily Hepatitis C Pill Effective Across 6 Genotypes.
Physician's First Watch, Nov 16, 2015
David G. Fairchild, MD, MPH, Editor-in-Chief
Massachusetts Medical Society
http://www.jwatch.org
- Foster GR, Afdhal N, Roberts SK et al
Sofosbuvir and Velpatasvir for HCV Genotype 2 and 3 Infection.
N Eng J Med. November 17, 2015
PMID: 26575258
http://www.nejm.org/doi/full/10.1056/NEJMoa1512612
- Ward JW, Mermin JH
Simple, Effective, but Out of Reach? Public Health Implications
of HCV Drugs.
N Eng J Med. November 17, 2015
PMID: 26575359
Component-of
sofosbuvir/velpatasvir (Epclusa)
sofosbuvir/velpatasvir/voxilaprevir (Vosevi)