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vascular endothelial growth factor (VEGF) inhibitor
Indications:
- VEGF inhibitors improve vision in diabetic macular edema [1]
- aflibercept may be most effective for worst baseline vision
- age-related macular degeneration [4]
- bevacizumab is used as an antineoplastic agent for metastatic colorectal cancer, lung cancer, ovarian cancer, breast cancer, malignant brain tumor, advanced cervical cancer, metastatic renal cell carcinoma
Dosage:
- intravitreous administration
Adverse effects:
- thrombotic microangiopathy
- hypertension [3]
Mechanism of action:
- inhibits vascular endothelial growth factor (VEGF)
Related
vascular endothelial growth factor family protein (VEGF family)
vascular endothelial growth factor [VEGF] receptor
Specific
aflibercept (Eylea)
bevacizumab (Avastin, Altuzan)
brolucizumab; brolucizumab-dbll (Beovu)
ranibizumab (Lucentis, Byooviz)
General
enzyme inhibitor
pharmaceutical angiogenesis inhibitor (angiostatic agent)
References
- The Diabetic Retinopathy Clinical Research Network.
Aflibercept, Bevacizumab, or Ranibizumab for Diabetic Macular Edema.
N Engl J Med. 2015 Feb 18.
PMID: 25692915
http://www.nejm.org/doi/full/10.1056/NEJMoa1414264
- Martin DF, Maguire MG.
Treatment Choice for Diabetic Macular Edema.
N Engl J Med. 2015 Feb 18. [Epub ahead of print]
PMID: 25692914
http://www.nejm.org/doi/full/10.1056/NEJMe1500351
- Usui J, Glezerman IG, Salvatore SP
Clinicopathological spectrum of kidney diseases in cancer patients
treated with vascular endothelial growth factor inhibitors:
a report of 5 cases and review of literature.
Hum Pathol. 2014 Sep;45(9):1918-27. Review.
PMID: 25087655
- Robinson ES, Khankin EV, Karumanchi SA, Humphreys BD.
Hypertension induced by vascular endothelial growth factor
signaling pathway inhibition: mechanisms and potential use
as a biomarker.
Semin Nephrol. 2010 Nov;30(6):591-601. Review.
PMID: 21146124 Free PMC Article
- Finger RP, Puth MT, Schmid M et al
Lifetime Outcomes of Anti-Vascular Endothelial Growth Factor Treatment
for Neovascular Age-Related Macular Degeneration.
JAMA Ophthalmol. 2020;138(12):1234-1240.
PMID: 33057589 PMCID: PMC7563682
https://jamanetwork.com/journals/jamaophthalmology/fullarticle/10.1001/jamaophthalmol.2020.3989