vasorin (protein Slit-like 2, VASN, SLITL2, UNQ314/PRO357/PRO1282)

Function: 1) inhibitor of TGF-beta signaling (putative) 2) interacts with TGFB1, TGFB2 & TGFB3 Structure: 1) N-glycosylated 2) contains 1 EGF-like domain. 3) contains 11 LRR repeats (leucine-rich repeats) Compartment: membrane, secreted Expression: - expressed in aorta > kidney, placenta > brain, heart, liver, lung, skeletal muscle - within aorta, strongest expression in tunica media - within kidney, expressed in interstitial cells

General

glycoprotein membrane protein secreted protein

Properties

SIZE: MW = 72 kD entity length = 673 aa COMPARTMENT: cellular membrane MOTIF: signal sequence {1-23} leucine-rich repeat SITE: 51-74 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 75-98 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 100-122 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N101} N-glycosylation site {N117} leucine-rich repeat SITE: 123-146 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 148-168 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 169-191 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 193-214 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 215-240 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 241-263 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 264-289 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N273} leucine-rich repeat SITE: 290-310 MOTIF: leucine residue (SEVERAL) EGF domain {405-442} MOTIF: cysteine residue {C409} MODIFICATION: cysteine residue {C420} cysteine residue {C414} MODIFICATION: cysteine residue {C430} cysteine residue {C420} MODIFICATION: cysteine residue {C409} cysteine residue {C430} MODIFICATION: cysteine residue {C414} cysteine residue {C432} MODIFICATION: cysteine residue {C441} cysteine residue {C441} MODIFICATION: cysteine residue {C432} fibronectin type III domain or F3 module {458-555} MOTIF: N-glycosylation site {N500} N-glycosylation site {N528} transmembrane domain {576-596}

Database Correlations

OMIM 608843 UniProt Q6EMK4 PFAM correlations

References

UniProt :accession Q6EMK4