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vasopressin V2 receptor; AVPR V2; renal-type arginine vasopressin receptor; antidiuretic hormone receptor (AVPR2 ADHR DIR DIR3 V2R)
Function:
- receptor for arginine vasopressin
- activity is mediated by G proteins which activate
- exerts antidiuretic effect in kidney
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Expression: kidney
Pathology:
- gain of function mutations in AVPR2 may be associated with syndrome of antidiuretic hormone secretion (SIADH)
- defects in AVPR2 are a cause
- of X-linked nephrogenic diabetes insipidus, type 1
General
glycoprotein
vasopressin receptor or antidiuretic hormone [ADH] receptor
Properties
SIZE: entity length = 371 aa
MW = 40 kD
COMPARTMENT: plasma membrane
MOTIF: exoplasmic domain {1-38}
MOTIF: N-glycosylation site {N22}
transmembrane domain {39-63}
cytoplasmic loop {64-77}
transmembrane domain {78-98}
exoplasmic loop {99-113}
transmembrane domain {114-135}
cytoplasmic loop {136-159}
transmembrane domain {160-180}
exoplasmic loop {181-200}
transmembrane domain {201-220}
cytoplasmic loop {221-271}
transmembrane domain {272-293}
exoplasmic loop {294-308}
transmembrane domain {309-328}
cytoplasmic domain {329-371}
MOTIF: cysteine residue {C341}
MODIFICATION: palmitate
COMPARTMENT: membrane
cysteine residue {C342}
MODIFICATION: palmitate
COMPARTMENT: membrane
Database Correlations
OMIM correlations
MORBIDMAP 300538
UniProt P30518
Pfam PF00001
Kegg hsa:554
References
- UniProt :accession P30518
- nephrogenic & neurogenic diabetes insipidus: AVPR2 pages
http://www.medicine.mcgill.ca/nephros/avpr2.html
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=AVPR2
- Yamamura Y et al
OPC-21268, an orally effective, nonpeptide vasopressin V1
receptor antagonist.
Science. 1991 Apr 26;252(5005):572-4.
PMID: 1850553