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vasopressin V1a receptor; V1aR; vascular/hepatic-type arginine vasopressin receptor; antidiuretic hormone receptor 1a; AVPR V1a (AVPR1A, AVPR1)
Function:
- receptor for arginine vasopressin
- activity is mediated by G proteins which activate a phosphatidyl-inositol-Ca+2 second messenger system
- mediates glycogenolysis in liver & vascular smooth muscle contraction in smooth muscle
- involved in social behaviors, including affiliation & attachment
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Expression:
- differences in regional receptor expression in the brain as well as differences in social behavior may result from a highly variable repetitive sequence in the 5' flanking region of AVPR1A
Pathology:
- one allelic variant has been linked to autism
General
glycoprotein
phosphoprotein
vasopressin receptor or antidiuretic hormone [ADH] receptor
Properties
SIZE: entity length = 418 aa
MW = 47 kD
COMPARTMENT: plasma membrane
MOTIF: exoplasmic domain {1-52}
MOTIF: N-glycosylation site {N27}
transmembrane domain {53-76}
cytoplasmic loop {77-88}
transmembrane domain {89-110}
exoplasmic loop {111-125}
MOTIF: cysteine residue {C124}
MODIFICATION: cysteine residue {C203}
transmembrane domain {126-147}
cytoplasmic loop {148-168}
transmembrane domain {169-190}
exoplasmic loop {191-218}
MOTIF: N-glycosylation site {N196}
cysteine residue {C203}
MODIFICATION: cysteine residue {C124}
transmembrane domain {219-239}
cytoplasmic loop {240-293}
transmembrane domain {294-313}
exoplasmic loop {314-331}
transmembrane domain {332-351}
cytoplasmic domain {352-418}
MOTIF: cysteine residue {C365}
MODIFICATION: palmitate
COMPARTMENT: membrane
cysteine residue {C366}
MODIFICATION: palmitate
COMPARTMENT: membrane
Ser phosphorylation site {S404}
Database Correlations
OMIM 600821
UniProt P37288
PFAM correlations
Kegg hsa:552
References
- UniProt :accession P37288
- Yamamura Y et al
OPC-21268, an orally effective, nonpeptide vasopressin V1
receptor antagonist.
Science. 1991 Apr 26;252(5005):572-4.
PMID: 1850553